Thyroid status regulates the tumor microenvironment delineating breast cancer fate
Abstract: The patient’s hormonal context plays a crucial role in the outcome of cancer. However, the association between thyroid disease and breast cancer risk remains unclear. We evaluated the effect of thyroid status on breast cancer growth and dissemination in an immunocompetent mouse model....
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Society for Endocrinology
2022
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/14115 |
| Aporte de: |
| id |
I33-R139-123456789-14115 |
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| record_format |
dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
CÁNCER DE MAMA HIPOTIROIDISMO HIPERTIROIDISMO INMUNIDAD ANTITUMORAL CELULAS MADRE MESENQUIMALES |
| spellingShingle |
CÁNCER DE MAMA HIPOTIROIDISMO HIPERTIROIDISMO INMUNIDAD ANTITUMORAL CELULAS MADRE MESENQUIMALES Sterle, Helena Andrea Hildebrandt, Ximena Valenzuela Álvarez, Matías Paulazo, Maria Alejandra Gutierrez, Luciana Mariel Klecha, Alicia Juana Cayrol, María Florencia Díaz Flaqué, María Celeste Rosemblit, Cinthia Barreiro Arcos, María Laura Colombo, Lucas Luis Bolontrade, Marcela Fabiana Medina, Vanina Araceli Cremaschi, Graciela A. Thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| topic_facet |
CÁNCER DE MAMA HIPOTIROIDISMO HIPERTIROIDISMO INMUNIDAD ANTITUMORAL CELULAS MADRE MESENQUIMALES |
| description |
Abstract:
The patient’s hormonal context plays a crucial role in the outcome of cancer. However,
the association between thyroid disease and breast cancer risk remains unclear. We
evaluated the effect of thyroid status on breast cancer growth and dissemination in an
immunocompetent mouse model. For this, hyperthyroid and hypothyroid Balb/c mice
were orthotopically inoculated with triple-negative breast cancer 4T1 cells. Tumors from
hyperthyroid mice showed an increased growth rate and an immunosuppressive tumor
microenvironment, characterized by increased IL-10 levels and decreased percentage
of activated cytotoxic T cells. On the other hand, delayed tumor growth in hypothyroid
animals was associated with increased tumor infiltration of activated CD8+ cells and a
high IFNγ/IL-10 ratio. Paradoxically, hypothyroid mice developed a higher number of
lung metastasis than hyperthyroid animals. This was related to an increased secretion
of tumor CCL2 and an immunosuppressive systemic environment, with increased
proportion of regulatory T cells and IL-10 levels in spleens. A lower number of lung
metastasis in hyperthyroid mice was related to the reduced presence of mesenchymal
stem cells in tumors and metastatic sites. These animals also exhibited decreased
percentages of regulatory T lymphocytes and myeloid-derived suppressor cells in spleens
but increased activated CD8+ cells and the IFNγ/IL-10 ratio. Therefore, thyroid hormones
modulate the cellular and cytokine content of the breast tumor microenvironment. A
better understanding of the mechanisms involved in these effects could be a starting
point for the discovery of new therapeutic targets for breast cancer. |
| format |
Artículo |
| author |
Sterle, Helena Andrea Hildebrandt, Ximena Valenzuela Álvarez, Matías Paulazo, Maria Alejandra Gutierrez, Luciana Mariel Klecha, Alicia Juana Cayrol, María Florencia Díaz Flaqué, María Celeste Rosemblit, Cinthia Barreiro Arcos, María Laura Colombo, Lucas Luis Bolontrade, Marcela Fabiana Medina, Vanina Araceli Cremaschi, Graciela A. |
| author_facet |
Sterle, Helena Andrea Hildebrandt, Ximena Valenzuela Álvarez, Matías Paulazo, Maria Alejandra Gutierrez, Luciana Mariel Klecha, Alicia Juana Cayrol, María Florencia Díaz Flaqué, María Celeste Rosemblit, Cinthia Barreiro Arcos, María Laura Colombo, Lucas Luis Bolontrade, Marcela Fabiana Medina, Vanina Araceli Cremaschi, Graciela A. |
| author_sort |
Sterle, Helena Andrea |
| title |
Thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| title_short |
Thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| title_full |
Thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| title_fullStr |
Thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| title_full_unstemmed |
Thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| title_sort |
thyroid status regulates the tumor microenvironment delineating breast cancer fate |
| publisher |
Society for Endocrinology |
| publishDate |
2022 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/14115 |
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