Histamine H4 receptor expression in triple negative breast cancer: an exploratory study

Abstract: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. There are neither universally accepted prognostic markers, nor molecular targets related to TNBC. The histamine H4 receptor (H4R) has been characterized in TNBC experimental models, demonstrating its critical r...

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Autores principales: Speisky, Daniela, Táquez Delgado, Mónica Alejandra, Iott, Alejandro, Nicoud, Melisa Beatriz, Ospital, Ignacio, Vigovich, Félix, Dezanzo, Pablo, Ernst, Glenda, Uriburu, Juan Luis, Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: SAGE 2022
Materias:
RECEPTOR DE HISTAMINA H4
INMUNOHISTOQUÍMICA
METÁSTASIS
MARCADOR PRONÓSTICO
CÁNCER DE MAMA TRIPLE NEGATIVO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14023
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14023
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic RECEPTOR DE HISTAMINA H4
INMUNOHISTOQUÍMICA
METÁSTASIS
MARCADOR PRONÓSTICO
CÁNCER DE MAMA TRIPLE NEGATIVO
spellingShingle RECEPTOR DE HISTAMINA H4
INMUNOHISTOQUÍMICA
METÁSTASIS
MARCADOR PRONÓSTICO
CÁNCER DE MAMA TRIPLE NEGATIVO
Speisky, Daniela
Táquez Delgado, Mónica Alejandra
Iott, Alejandro
Nicoud, Melisa Beatriz
Ospital, Ignacio
Vigovich, Félix
Dezanzo, Pablo
Ernst, Glenda
Uriburu, Juan Luis
Medina, Vanina Araceli
Histamine H4 receptor expression in triple negative breast cancer: an exploratory study
topic_facet RECEPTOR DE HISTAMINA H4
INMUNOHISTOQUÍMICA
METÁSTASIS
MARCADOR PRONÓSTICO
CÁNCER DE MAMA TRIPLE NEGATIVO
description Abstract: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. There are neither universally accepted prognostic markers, nor molecular targets related to TNBC. The histamine H4 receptor (H4R) has been characterized in TNBC experimental models, demonstrating its critical role in tumor development and progression. In this study, H4R expression was compared in breast cancer subtypes and correlated with clinical features using The Cancer Genome Atlas data (TCGA, Pan-Cancer Atlas). The H4R status was further evaluated by immunohistochemistry in 30 TNBC human samples in relation to clinicopathological parameters. Results indicate that H4R was downregulated in basal-like/TNBC compared with luminal A and normal breastlike tumors. The higher expression of H4R was associated with improved progression free and overall survival outcomes in basal-like/TNBC. H4R immunoreactivity was detected in about 70% of tumors, and its expression was positively correlated with the levels in the histologically normal peritumoral tissue. High H4R expression in peritumoral tissue correlated with reduced number of lymph node involvement and unifocal TNBC while it was associated with increased patient survival. In conclusion, the H4R might represent a potential prognostic biomarker in TNBC. Further studies in large cohorts are needed to better understand the significance of H4R in breast cancer biology.
format Artículo
author Speisky, Daniela
Táquez Delgado, Mónica Alejandra
Iott, Alejandro
Nicoud, Melisa Beatriz
Ospital, Ignacio
Vigovich, Félix
Dezanzo, Pablo
Ernst, Glenda
Uriburu, Juan Luis
Medina, Vanina Araceli
author_facet Speisky, Daniela
Táquez Delgado, Mónica Alejandra
Iott, Alejandro
Nicoud, Melisa Beatriz
Ospital, Ignacio
Vigovich, Félix
Dezanzo, Pablo
Ernst, Glenda
Uriburu, Juan Luis
Medina, Vanina Araceli
author_sort Speisky, Daniela
title Histamine H4 receptor expression in triple negative breast cancer: an exploratory study
title_short Histamine H4 receptor expression in triple negative breast cancer: an exploratory study
title_full Histamine H4 receptor expression in triple negative breast cancer: an exploratory study
title_fullStr Histamine H4 receptor expression in triple negative breast cancer: an exploratory study
title_full_unstemmed Histamine H4 receptor expression in triple negative breast cancer: an exploratory study
title_sort histamine h4 receptor expression in triple negative breast cancer: an exploratory study
publisher SAGE
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14023
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