Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease

Abstract: A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LO...

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Detalles Bibliográficos
Autores principales: Duarte Abritta, Bárbara, Sánchez, Stella Maris, Abulafia, Carolina Andrea, Gustafson, Deborah R., Vázquez, Silvia, Sevlever, Gustavo, Castro, Mariana N., Fiorentini, Leticia, Villarreal, Mirta F., Guinjoan, Salvador M.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
ENFERMEDAD DE ALZHEIMER
RESONANCIA MAGNETICA NUCLEAR
BIOMARCADORES
PET-PiB
FUNCIONES EJECUTIVAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14018
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14018
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE ALZHEIMER
RESONANCIA MAGNETICA NUCLEAR
BIOMARCADORES
PET-PiB
FUNCIONES EJECUTIVAS
spellingShingle ENFERMEDAD DE ALZHEIMER
RESONANCIA MAGNETICA NUCLEAR
BIOMARCADORES
PET-PiB
FUNCIONES EJECUTIVAS
Duarte Abritta, Bárbara
Sánchez, Stella Maris
Abulafia, Carolina Andrea
Gustafson, Deborah R.
Vázquez, Silvia
Sevlever, Gustavo
Castro, Mariana N.
Fiorentini, Leticia
Villarreal, Mirta F.
Guinjoan, Salvador M.
Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
topic_facet ENFERMEDAD DE ALZHEIMER
RESONANCIA MAGNETICA NUCLEAR
BIOMARCADORES
PET-PiB
FUNCIONES EJECUTIVAS
description Abstract: A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature.
format Artículo
author Duarte Abritta, Bárbara
Sánchez, Stella Maris
Abulafia, Carolina Andrea
Gustafson, Deborah R.
Vázquez, Silvia
Sevlever, Gustavo
Castro, Mariana N.
Fiorentini, Leticia
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_facet Duarte Abritta, Bárbara
Sánchez, Stella Maris
Abulafia, Carolina Andrea
Gustafson, Deborah R.
Vázquez, Silvia
Sevlever, Gustavo
Castro, Mariana N.
Fiorentini, Leticia
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_sort Duarte Abritta, Bárbara
title Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
title_short Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
title_full Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
title_fullStr Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
title_full_unstemmed Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
title_sort amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset alzheimer's disease
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14018
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