Circadian rhythms in bacterial sepsis pathology : what we know and what we should know

Abstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients underg...

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Autores principales: Mul Fedele, Malena Lis, Senna, Camila Agustina, Aiello, Ignacio, Golombek, Diego A., Paladino, Natalia
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers 2022
Materias:
RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13955
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-13955
record_format dspace
spelling I33-R139-123456789-139552023-11-22T22:08:15Z Circadian rhythms in bacterial sepsis pathology : what we know and what we should know Mul Fedele, Malena Lis Senna, Camila Agustina Aiello, Ignacio Golombek, Diego A. Paladino, Natalia RITMO CIRCADIANO SISTEMA INMUNOLOGICO HIPOTERMIA SEPSIS INFECCIONES Abstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian systemin sepsis pathology could be an important tool to improve patient therapies. 2022-05-13T12:43:14Z 2022-05-13T12:43:14Z 2021 Artículo Mul Fedele, M. L. et al. Circadian rhythms in bacterial sepsis pathology : what we know and what we should know [en línea]. Frontiers in cellular and infection microbiology. 2021, 11. doi: 10.3389/fcimb.2021.773181. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13955 2235-2988 (on line) https://repositorio.uca.edu.ar/handle/123456789/13955 10.3389/fcimb.2021.773181 34956930 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Frontiers in cellular and infection microbiology. 2021, 11
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
spellingShingle RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego A.
Paladino, Natalia
Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
topic_facet RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
description Abstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian systemin sepsis pathology could be an important tool to improve patient therapies.
format Artículo
author Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego A.
Paladino, Natalia
author_facet Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego A.
Paladino, Natalia
author_sort Mul Fedele, Malena Lis
title Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_short Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_full Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_fullStr Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_full_unstemmed Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_sort circadian rhythms in bacterial sepsis pathology : what we know and what we should know
publisher Frontiers
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13955
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AT sennacamilaagustina circadianrhythmsinbacterialsepsispathologywhatweknowandwhatweshouldknow
AT aielloignacio circadianrhythmsinbacterialsepsispathologywhatweknowandwhatweshouldknow
AT golombekdiegoa circadianrhythmsinbacterialsepsispathologywhatweknowandwhatweshouldknow
AT paladinonatalia circadianrhythmsinbacterialsepsispathologywhatweknowandwhatweshouldknow
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