Persistence of spatial memory induced by spaced training involves a behavioral-tagging process

"Spaced training, which involves long inter-trial intervals, has positive effects on memories. One of the main attributes of long-term memories (LTM) is persistence. Here, to identify the process that promotes LTM persistence by spaced learning, we used the spatial object recognition (SOR) task...

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Autores principales: Correa, Julieta, Tintorelli, Ramiro, Budriesi, Pablo, Viola, Haydeé
Formato: Artículo de Publicación Periódica acceptedVersion
Lenguaje:Inglés
Publicado: 2023
Materias:
APRENDIZAJE
MEMORIA
CONSOLIDACION DE LA MEMORIA
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/4128
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-4128
record_format dspace
spelling I32-R138-123456789-41282023-01-05T03:02:15Z Persistence of spatial memory induced by spaced training involves a behavioral-tagging process Correa, Julieta Tintorelli, Ramiro Budriesi, Pablo Viola, Haydeé APRENDIZAJE MEMORIA CONSOLIDACION DE LA MEMORIA "Spaced training, which involves long inter-trial intervals, has positive effects on memories. One of the main attributes of long-term memories (LTM) is persistence. Here, to identify the process that promotes LTM persistence by spaced learning, we used the spatial object recognition (SOR) task in rats. The protocol consisted of a first strong training session that induced LTM formation (tested 1 day after training), but not LTM persistence (tested 7 or 14 days after training); and a second weak training session that promoted memory persistence when applied 1 day, but not 7 days, after the first training. We propose that the promotion of memory persistence is based on the Behavioral Tagging (BT) mechanism operating when the memory trace is retrieved. BT involves the setting of a tag induced by learning which gives rise to input selectivity, and the use of plasticity-related proteins (PRPs) to establish the mnemonic trace. We postulate that retraining will mainly retag the sites initially activated by the original learning, where the PRPs needed for memory expression and/or induced by retrieval would be used to maintain a persistent mnemonic trace. Our results suggest that the mechanism of memory expression, but not those of memory reinforcement or reconsolidation, is necessary to promote memory persistence after retraining. The molecular mechanisms involve ERKs1/2 activity to set the SOR learning tag, and the availability of GluA2-containing AMPA receptor. In conclusion, both the synthesis of PRPs and the setting of learning tags are key processes triggered by retraining that allow SOR memory persistence." 2023-01-03T15:08:26Z 2023-01-03T15:08:26Z 2022-08-10 Artículo de Publicación Periódica info:eu-repo/semantics/acceptedVersion 0306-4522 https://ri.itba.edu.ar/handle/123456789/4128 en info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2022.02.032 info:eu-repo/grantAgreement/ANPCyT/PICT/2016-0172/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/UBA/UBACyT/20020170100501BA/AR. Ciudad Autónoma de Buenos Aires application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic APRENDIZAJE
MEMORIA
CONSOLIDACION DE LA MEMORIA
spellingShingle APRENDIZAJE
MEMORIA
CONSOLIDACION DE LA MEMORIA
Correa, Julieta
Tintorelli, Ramiro
Budriesi, Pablo
Viola, Haydeé
Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
topic_facet APRENDIZAJE
MEMORIA
CONSOLIDACION DE LA MEMORIA
description "Spaced training, which involves long inter-trial intervals, has positive effects on memories. One of the main attributes of long-term memories (LTM) is persistence. Here, to identify the process that promotes LTM persistence by spaced learning, we used the spatial object recognition (SOR) task in rats. The protocol consisted of a first strong training session that induced LTM formation (tested 1 day after training), but not LTM persistence (tested 7 or 14 days after training); and a second weak training session that promoted memory persistence when applied 1 day, but not 7 days, after the first training. We propose that the promotion of memory persistence is based on the Behavioral Tagging (BT) mechanism operating when the memory trace is retrieved. BT involves the setting of a tag induced by learning which gives rise to input selectivity, and the use of plasticity-related proteins (PRPs) to establish the mnemonic trace. We postulate that retraining will mainly retag the sites initially activated by the original learning, where the PRPs needed for memory expression and/or induced by retrieval would be used to maintain a persistent mnemonic trace. Our results suggest that the mechanism of memory expression, but not those of memory reinforcement or reconsolidation, is necessary to promote memory persistence after retraining. The molecular mechanisms involve ERKs1/2 activity to set the SOR learning tag, and the availability of GluA2-containing AMPA receptor. In conclusion, both the synthesis of PRPs and the setting of learning tags are key processes triggered by retraining that allow SOR memory persistence."
format Artículo de Publicación Periódica
acceptedVersion
author Correa, Julieta
Tintorelli, Ramiro
Budriesi, Pablo
Viola, Haydeé
author_facet Correa, Julieta
Tintorelli, Ramiro
Budriesi, Pablo
Viola, Haydeé
author_sort Correa, Julieta
title Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
title_short Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
title_full Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
title_fullStr Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
title_full_unstemmed Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
title_sort persistence of spatial memory induced by spaced training involves a behavioral-tagging process
publishDate 2023
url https://ri.itba.edu.ar/handle/123456789/4128
work_keys_str_mv AT correajulieta persistenceofspatialmemoryinducedbyspacedtraininginvolvesabehavioraltaggingprocess
AT tintorelliramiro persistenceofspatialmemoryinducedbyspacedtraininginvolvesabehavioraltaggingprocess
AT budriesipablo persistenceofspatialmemoryinducedbyspacedtraininginvolvesabehavioraltaggingprocess
AT violahaydee persistenceofspatialmemoryinducedbyspacedtraininginvolvesabehavioraltaggingprocess
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