Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence

"Dopamine (DA) neurons in the ventral tegmental area (VTA) innervating several limbic and neocortical regions of the mammalian brain have long been implicated in motivation, rewarding and aversive behaviors, and memory processing. Recently, we demonstrated that somatodendritic release of DA in...

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Autores principales: Castillo Díaz, Fernando, Dalto, Juliana F., Pereyra, Magdalena, Medina, Jorge Horacio
Formato: Artículo de Publicación Periódica acceptedVersion
Lenguaje:Inglés
Publicado: 2023
Materias:
DOPAMINA
CONSOLIDACION DE LA MEMORIA
NEURONAS
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/4127
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-4127
record_format dspace
spelling I32-R138-123456789-41272023-01-13T12:54:07Z Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence Castillo Díaz, Fernando Dalto, Juliana F. Pereyra, Magdalena Medina, Jorge Horacio DOPAMINA CONSOLIDACION DE LA MEMORIA NEURONAS "Dopamine (DA) neurons in the ventral tegmental area (VTA) innervating several limbic and neocortical regions of the mammalian brain have long been implicated in motivation, rewarding and aversive behaviors, and memory processing. Recently, we demonstrated that somatodendritic release of DA in the VTA regulates the formation and maintenance of appetitive long-term memories (LTM). However, less is known about the impact of DA neurotransmission in the VTA on aversive LTM. Here, we describe the modulation of negative-valence memories by D1/D5-type DA (D1R)-receptor-mediated neurotransmission in the VTA. As aversive stimuli elicit both active and passive behavioral responses, we used two single-trial aversive training protocols: inhibitory avoidance task and conditioned place aversion. We bilaterally microinfused SCH23390, an antagonist of D1R, into the VTA immediately after training and found that DA neurotransmission in the VTA modulates LTM consolidation and persistence of aversive experiences. Together with previous findings demonstrating that D1R mediated DA neurotransmission in the medial prefrontal cortex and hippocampus is involved in the formation and persistence of LTM for aversive events, our present results indicate that memory processing of environmental stimuli with negative-valence depends on the integration of information mediated by D1R activation in both the VTA region and in selected downstream target areas." 2023-01-03T14:24:47Z 2023-01-03T14:24:47Z 2022-09-01 Artículo de Publicación Periódica info:eu-repo/semantics/acceptedVersion 0031-9384 https://ri.itba.edu.ar/handle/123456789/4127 en info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2022.113854 application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic DOPAMINA
CONSOLIDACION DE LA MEMORIA
NEURONAS
spellingShingle DOPAMINA
CONSOLIDACION DE LA MEMORIA
NEURONAS
Castillo Díaz, Fernando
Dalto, Juliana F.
Pereyra, Magdalena
Medina, Jorge Horacio
Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence
topic_facet DOPAMINA
CONSOLIDACION DE LA MEMORIA
NEURONAS
description "Dopamine (DA) neurons in the ventral tegmental area (VTA) innervating several limbic and neocortical regions of the mammalian brain have long been implicated in motivation, rewarding and aversive behaviors, and memory processing. Recently, we demonstrated that somatodendritic release of DA in the VTA regulates the formation and maintenance of appetitive long-term memories (LTM). However, less is known about the impact of DA neurotransmission in the VTA on aversive LTM. Here, we describe the modulation of negative-valence memories by D1/D5-type DA (D1R)-receptor-mediated neurotransmission in the VTA. As aversive stimuli elicit both active and passive behavioral responses, we used two single-trial aversive training protocols: inhibitory avoidance task and conditioned place aversion. We bilaterally microinfused SCH23390, an antagonist of D1R, into the VTA immediately after training and found that DA neurotransmission in the VTA modulates LTM consolidation and persistence of aversive experiences. Together with previous findings demonstrating that D1R mediated DA neurotransmission in the medial prefrontal cortex and hippocampus is involved in the formation and persistence of LTM for aversive events, our present results indicate that memory processing of environmental stimuli with negative-valence depends on the integration of information mediated by D1R activation in both the VTA region and in selected downstream target areas."
format Artículo de Publicación Periódica
acceptedVersion
author Castillo Díaz, Fernando
Dalto, Juliana F.
Pereyra, Magdalena
Medina, Jorge Horacio
author_facet Castillo Díaz, Fernando
Dalto, Juliana F.
Pereyra, Magdalena
Medina, Jorge Horacio
author_sort Castillo Díaz, Fernando
title Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence
title_short Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence
title_full Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence
title_fullStr Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence
title_full_unstemmed Dopamine neurotransmission in the VTA regulates aversive memory formation and persistence
title_sort dopamine neurotransmission in the vta regulates aversive memory formation and persistence
publishDate 2023
url https://ri.itba.edu.ar/handle/123456789/4127
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AT daltojulianaf dopamineneurotransmissioninthevtaregulatesaversivememoryformationandpersistence
AT pereyramagdalena dopamineneurotransmissioninthevtaregulatesaversivememoryformationandpersistence
AT medinajorgehoracio dopamineneurotransmissioninthevtaregulatesaversivememoryformationandpersistence
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