The effect of zolpidem on targeted memory reactivation during sleep

"According to the active system consolidation theory, memory consolidation during sleep relies on the reactivation of newly encoded memory representations. This reactivation is orchestrated by the interplay of sleep slow oscillations, spindles, and theta, which are in turn modulated by certain...

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Autores principales: Carbone, Julia, Bibián, Carlos, Reischl, Patrick, Born, Jan, Forcato, Cecilia, Diekelmann, Susanne
Formato: publishedVersion Artículo de Publicación Periódica SUEÑO Y MEMORIA APRENDIZAJE
Lenguaje:Inglés
Publicado: 2022
Materias:
CONSOLIDACION DE LA MEMORIA
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/4089
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Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-4089
record_format dspace
spelling I32-R138-123456789-40892023-01-03T11:16:09Z The effect of zolpidem on targeted memory reactivation during sleep Carbone, Julia Bibián, Carlos Reischl, Patrick Born, Jan Forcato, Cecilia Diekelmann, Susanne CONSOLIDACION DE LA MEMORIA "According to the active system consolidation theory, memory consolidation during sleep relies on the reactivation of newly encoded memory representations. This reactivation is orchestrated by the interplay of sleep slow oscillations, spindles, and theta, which are in turn modulated by certain neurotransmitters like GABA to enable long-lasting plastic changes in the memory store. Here we asked whether the GABAergic system and associated changes in sleep oscillations are functionally related to memory reactivation during sleep. We administered the GABAA agonist zolpidem (10 mg) in a double-blind placebo-controlled study. To specifically focus on the effects on memory reactivation during sleep, we experimentally induced such reactivations by targeted memory reactivation (TMR) with learning-associated reminder cues presented during post-learning slow-wave sleep (SWS). Zolpidem significantly enhanced memory performance with TMR during sleep compared with placebo. Zolpidem also increased the coupling of fast spindles and theta to slow oscillations, although overall the power of slow spindles and theta was reduced compared with placebo. In an uncorrected exploratory analysis, memory performance was associated with slow spindle responses to TMR in the zolpidem condition, whereas it was asso ciated with fast spindle responses in placebo. These findings provide tentative first evidence that GABAergic activity may be functionally implicated in memory reactivation processes during sleep, possibly via its effects on slow oscillations, spindles and theta as well as their interplay." 2022-12-15T18:39:50Z 2022-12-15T18:39:50Z 2021 info:eu-repo/semantics/publishedVersion Artículo de Publicación Periódica SUEÑO Y MEMORIA APRENDIZAJE 1072-0502 https://ri.itba.edu.ar/handle/123456789/4089 en info:eu-repo/semantics/reference/doi/10.1101/lm.052787.120. application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CONSOLIDACION DE LA MEMORIA
spellingShingle CONSOLIDACION DE LA MEMORIA
Carbone, Julia
Bibián, Carlos
Reischl, Patrick
Born, Jan
Forcato, Cecilia
Diekelmann, Susanne
The effect of zolpidem on targeted memory reactivation during sleep
topic_facet CONSOLIDACION DE LA MEMORIA
description "According to the active system consolidation theory, memory consolidation during sleep relies on the reactivation of newly encoded memory representations. This reactivation is orchestrated by the interplay of sleep slow oscillations, spindles, and theta, which are in turn modulated by certain neurotransmitters like GABA to enable long-lasting plastic changes in the memory store. Here we asked whether the GABAergic system and associated changes in sleep oscillations are functionally related to memory reactivation during sleep. We administered the GABAA agonist zolpidem (10 mg) in a double-blind placebo-controlled study. To specifically focus on the effects on memory reactivation during sleep, we experimentally induced such reactivations by targeted memory reactivation (TMR) with learning-associated reminder cues presented during post-learning slow-wave sleep (SWS). Zolpidem significantly enhanced memory performance with TMR during sleep compared with placebo. Zolpidem also increased the coupling of fast spindles and theta to slow oscillations, although overall the power of slow spindles and theta was reduced compared with placebo. In an uncorrected exploratory analysis, memory performance was associated with slow spindle responses to TMR in the zolpidem condition, whereas it was asso ciated with fast spindle responses in placebo. These findings provide tentative first evidence that GABAergic activity may be functionally implicated in memory reactivation processes during sleep, possibly via its effects on slow oscillations, spindles and theta as well as their interplay."
format publishedVersion
Artículo de Publicación Periódica
SUEÑO Y MEMORIA
APRENDIZAJE
author Carbone, Julia
Bibián, Carlos
Reischl, Patrick
Born, Jan
Forcato, Cecilia
Diekelmann, Susanne
author_facet Carbone, Julia
Bibián, Carlos
Reischl, Patrick
Born, Jan
Forcato, Cecilia
Diekelmann, Susanne
author_sort Carbone, Julia
title The effect of zolpidem on targeted memory reactivation during sleep
title_short The effect of zolpidem on targeted memory reactivation during sleep
title_full The effect of zolpidem on targeted memory reactivation during sleep
title_fullStr The effect of zolpidem on targeted memory reactivation during sleep
title_full_unstemmed The effect of zolpidem on targeted memory reactivation during sleep
title_sort effect of zolpidem on targeted memory reactivation during sleep
publishDate 2022
url https://ri.itba.edu.ar/handle/123456789/4089
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