Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory

"The retrosplenial cortex (RSC) has been widely related to spatial and contextual memory. However, we recently demonstrated that the anterior part of the RSC (aRSC) is required for object recognition (OR) memory consolidation. In this study, we aimed to analyze the requirement of dopaminergic i...

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Autores principales: de Landeta, Ana Belén, Medina, Jorge Horacio, Katche, Cynthia
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2022
Materias:
DOPAMINA
MEMORIA
CEREBRO
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/3952
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3952
record_format dspace
spelling I32-R138-123456789-39522023-01-13T12:53:08Z Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory de Landeta, Ana Belén Medina, Jorge Horacio Katche, Cynthia DOPAMINA MEMORIA CEREBRO "The retrosplenial cortex (RSC) has been widely related to spatial and contextual memory. However, we recently demonstrated that the anterior part of the RSC (aRSC) is required for object recognition (OR) memory consolidation. In this study, we aimed to analyze the requirement of dopaminergic inputs into the aRSC for OR memory consolidation in male rats. We observed amnesia at 24-h long-term memory when we infused SCH23390, a D1/D5 dopamine receptors antagonist, into aRSC immediately after OR training session. However, the same infusion had no effect on OR short-term memory. Then, we analyzed whether the ventral tegmental area (VTA) is necessary for OR consolidation. VTA inactivation by intra-VTA administration of muscimol, a GABAA agonist, immediately after an OR training session induced amnesia when animals were tested at 24 h. Moreover, we observed that this VTA inactivation-induced amnesia was reversed by the simultaneous intra-aRSC delivery of SKF38393, a D1/D5 receptor agonist. Altogether, our results suggest that VTA dopaminergic inputs to aRSC play an important modulatory role in OR memory consolidation." 2022-11-01T15:16:55Z 2022-11-01T15:16:55Z 2022-07-22 Article info:eu-repo/semantics/publishedVersion 1662-5153 https://ri.itba.edu.ar/handle/123456789/3952 en info:eu-repo/semantics/altIdentifier/doi/10.3389/fnbeh.2022.922971 info:eu-repo/grantAgreement/ANPCyT/PICT/2018-00762/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/CONICET/AR. Ciudad Autónoma de Buenos Aires http://creativecommons.org/licenses/by-nc-sa/X.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic DOPAMINA
MEMORIA
CEREBRO
spellingShingle DOPAMINA
MEMORIA
CEREBRO
de Landeta, Ana Belén
Medina, Jorge Horacio
Katche, Cynthia
Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
topic_facet DOPAMINA
MEMORIA
CEREBRO
description "The retrosplenial cortex (RSC) has been widely related to spatial and contextual memory. However, we recently demonstrated that the anterior part of the RSC (aRSC) is required for object recognition (OR) memory consolidation. In this study, we aimed to analyze the requirement of dopaminergic inputs into the aRSC for OR memory consolidation in male rats. We observed amnesia at 24-h long-term memory when we infused SCH23390, a D1/D5 dopamine receptors antagonist, into aRSC immediately after OR training session. However, the same infusion had no effect on OR short-term memory. Then, we analyzed whether the ventral tegmental area (VTA) is necessary for OR consolidation. VTA inactivation by intra-VTA administration of muscimol, a GABAA agonist, immediately after an OR training session induced amnesia when animals were tested at 24 h. Moreover, we observed that this VTA inactivation-induced amnesia was reversed by the simultaneous intra-aRSC delivery of SKF38393, a D1/D5 receptor agonist. Altogether, our results suggest that VTA dopaminergic inputs to aRSC play an important modulatory role in OR memory consolidation."
format Article
publishedVersion
author de Landeta, Ana Belén
Medina, Jorge Horacio
Katche, Cynthia
author_facet de Landeta, Ana Belén
Medina, Jorge Horacio
Katche, Cynthia
author_sort de Landeta, Ana Belén
title Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
title_short Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
title_full Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
title_fullStr Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
title_full_unstemmed Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
title_sort dopamine d1/d5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
publishDate 2022
url https://ri.itba.edu.ar/handle/123456789/3952
work_keys_str_mv AT delandetaanabelen dopamined1d5receptorsintherestrosplenialcortexarenecessarytoconsolidateobjectrecognitionmemory
AT medinajorgehoracio dopamined1d5receptorsintherestrosplenialcortexarenecessarytoconsolidateobjectrecognitionmemory
AT katchecynthia dopamined1d5receptorsintherestrosplenialcortexarenecessarytoconsolidateobjectrecognitionmemory
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