Non-linear susceptibility to interferences in declarative memory formation

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"After encoding, memories go through a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder of the original memory, followed by a period of re-stabilization (reconsolidation). During the...

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Autores principales: Moyano, Malen D., Carbonari, Giulia, Bonilla, Matías, Pedreira, María Eugenia, Brusco, Luis Ignacio, Kaczer, Laura, Forcato, Cecilia
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2022
Materias:
CONSOLIDACION DE LA MEMORIA
MEMORIA
CEREBRO
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/3947
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3947
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spelling I32-R138-123456789-39472022-12-07T13:06:29Z Non-linear susceptibility to interferences in declarative memory formation Moyano, Malen D. Carbonari, Giulia Bonilla, Matías Pedreira, María Eugenia Brusco, Luis Ignacio Kaczer, Laura Forcato, Cecilia CONSOLIDACION DE LA MEMORIA MEMORIA CEREBRO "After encoding, memories go through a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder of the original memory, followed by a period of re-stabilization (reconsolidation). During these periods of lability the memory traces can be modified. Currently, some studies show a rapid stabilization after 30 min, while others show that stabilization occurs after longer periods (e.g. > 6 h). Here we investigate the effect of an interference treatment on declarative memory consolidation, comparing distinct time intervals after acquisition. On day 1, participants learned a list of non- syllable pairs (List 1). 5 min, 30 min, 3 h or 8 h later, they received an interference list (List 2) that acted as an amnesic agent. On day 2 (48 h after training) participants had to recall List 1 first, followed by List 2. We found that the List 1 memory was susceptible to interference when List 2 was administered 5 min or 3 h after learning but not when it was administered 30 min or 8 h after. We propose the possibility that this rapid memory protection could be induced by a fast and transient neocortical integration. Our results open a discussion about the contribution of molecular and systemic aspects to memory consolidation." 2022-10-31T19:02:05Z 2022-10-31T19:02:05Z 2022-06-29 Article info:eu-repo/semantics/publishedVersion https://ri.itba.edu.ar/handle/123456789/3947 en info:eu-repo/semantics/dataset/doi/10.1371/journal.pone.0270678 info:eu-repo/grantAgreement/CONICET/PICT/2016-0229/AR. Ciudad Autónoma de Buenos Aires https://creativecommons.org/licenses/by-nc-sa/X.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CONSOLIDACION DE LA MEMORIA
MEMORIA
CEREBRO
spellingShingle CONSOLIDACION DE LA MEMORIA
MEMORIA
CEREBRO
Moyano, Malen D.
Carbonari, Giulia
Bonilla, Matías
Pedreira, María Eugenia
Brusco, Luis Ignacio
Kaczer, Laura
Forcato, Cecilia
Non-linear susceptibility to interferences in declarative memory formation
topic_facet CONSOLIDACION DE LA MEMORIA
MEMORIA
CEREBRO
description "After encoding, memories go through a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder of the original memory, followed by a period of re-stabilization (reconsolidation). During these periods of lability the memory traces can be modified. Currently, some studies show a rapid stabilization after 30 min, while others show that stabilization occurs after longer periods (e.g. > 6 h). Here we investigate the effect of an interference treatment on declarative memory consolidation, comparing distinct time intervals after acquisition. On day 1, participants learned a list of non- syllable pairs (List 1). 5 min, 30 min, 3 h or 8 h later, they received an interference list (List 2) that acted as an amnesic agent. On day 2 (48 h after training) participants had to recall List 1 first, followed by List 2. We found that the List 1 memory was susceptible to interference when List 2 was administered 5 min or 3 h after learning but not when it was administered 30 min or 8 h after. We propose the possibility that this rapid memory protection could be induced by a fast and transient neocortical integration. Our results open a discussion about the contribution of molecular and systemic aspects to memory consolidation."
format Article
publishedVersion
author Moyano, Malen D.
Carbonari, Giulia
Bonilla, Matías
Pedreira, María Eugenia
Brusco, Luis Ignacio
Kaczer, Laura
Forcato, Cecilia
author_facet Moyano, Malen D.
Carbonari, Giulia
Bonilla, Matías
Pedreira, María Eugenia
Brusco, Luis Ignacio
Kaczer, Laura
Forcato, Cecilia
author_sort Moyano, Malen D.
title Non-linear susceptibility to interferences in declarative memory formation
title_short Non-linear susceptibility to interferences in declarative memory formation
title_full Non-linear susceptibility to interferences in declarative memory formation
title_fullStr Non-linear susceptibility to interferences in declarative memory formation
title_full_unstemmed Non-linear susceptibility to interferences in declarative memory formation
title_sort non-linear susceptibility to interferences in declarative memory formation
publishDate 2022
url https://ri.itba.edu.ar/handle/123456789/3947
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