Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach

"Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released o...

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Autores principales: Colmegna, Patricio, Bianchi, Fernando D., Sánchez-Peña, Ricardo
Formato: Artículos de Publicaciones Periódicas acceptedVersion
Lenguaje:Inglés
Publicado: info
Materias:
DIABETES
PANCREAS
ORGANOS ARTIFICIALES
CONTROL DE VARIACION LINEAL DE PARAMETROS
INSULINA
GLUCOSA
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/3312
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3312
record_format dspace
spelling I32-R138-123456789-33122022-12-07T13:06:44Z Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach Colmegna, Patricio Bianchi, Fernando D. Sánchez-Peña, Ricardo DIABETES PANCREAS ORGANOS ARTIFICIALES CONTROL DE VARIACION LINEAL DE PARAMETROS INSULINA GLUCOSA "Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this paper, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closedloop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia." info:eu-repo/date/embargoEnd/2023-03-17 2021-01-22T13:49:34Z 2021-01-22T13:49:34Z 2021 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion 2475-1456 http://ri.itba.edu.ar/handle/123456789/3312 en info:eu-repo/semantics/reference/10.1109/LCSYS.2020.3041211 info:eu-repo/grantAgreement/Fundación Cellex/ES. Barcelona info:eu-repo/grantAgreement/Fundación Nuria/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/JDRF/APF/2-APF-2019-373-A-N/US. Nueva York, NY info:eu-repo/semantics/embargoedAccess application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic DIABETES
PANCREAS
ORGANOS ARTIFICIALES
CONTROL DE VARIACION LINEAL DE PARAMETROS
INSULINA
GLUCOSA
spellingShingle DIABETES
PANCREAS
ORGANOS ARTIFICIALES
CONTROL DE VARIACION LINEAL DE PARAMETROS
INSULINA
GLUCOSA
Colmegna, Patricio
Bianchi, Fernando D.
Sánchez-Peña, Ricardo
Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach
topic_facet DIABETES
PANCREAS
ORGANOS ARTIFICIALES
CONTROL DE VARIACION LINEAL DE PARAMETROS
INSULINA
GLUCOSA
description "Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this paper, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closedloop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia."
format Artículos de Publicaciones Periódicas
acceptedVersion
author Colmegna, Patricio
Bianchi, Fernando D.
Sánchez-Peña, Ricardo
author_facet Colmegna, Patricio
Bianchi, Fernando D.
Sánchez-Peña, Ricardo
author_sort Colmegna, Patricio
title Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach
title_short Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach
title_full Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach
title_fullStr Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach
title_full_unstemmed Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach
title_sort automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched lpv approach
publishDate info
url http://ri.itba.edu.ar/handle/123456789/3312
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