Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

"Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete remin...

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Autores principales: Forcato, Cecilia, Klinzing, Jens G., Carbone, Julia, Radloff, Michael, Weber, Frederik D., Born, Jan, Diekelmann, Susanne
Formato: Artículos de Publicaciones Periódicas publishedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
CONSOLIDACION DE LA MEMORIA
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/3244
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Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3244
record_format dspace
spelling I32-R138-123456789-32442022-12-07T13:05:43Z Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans Forcato, Cecilia Klinzing, Jens G. Carbone, Julia Radloff, Michael Weber, Frederik D. Born, Jan Diekelmann, Susanne CONSOLIDACION DE LA MEMORIA "Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection." 2020-12-09T15:22:22Z 2020-12-09T15:22:22Z 2020-12-04 Artículos de Publicaciones Periódicas info:eu-repo/semantics/publishedVersion 2399-3642 http://ri.itba.edu.ar/handle/123456789/3244 en info:eu-repo/semantics/reference/doi/10.1038/s42003-020-01457-4 info:eu-repo/semantics/dataset/doi/10.1038/s42003-020-01457-4 info:eu-repo/grantAgreement/DFG/TR-SFB 654/DE. Berlín info:eu-repo/grantAgreement/CONICET/AR. Ciudad Autónoma de Buenos Aires https://creativecommons.org/licenses/by/4.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CONSOLIDACION DE LA MEMORIA
spellingShingle CONSOLIDACION DE LA MEMORIA
Forcato, Cecilia
Klinzing, Jens G.
Carbone, Julia
Radloff, Michael
Weber, Frederik D.
Born, Jan
Diekelmann, Susanne
Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
topic_facet CONSOLIDACION DE LA MEMORIA
description "Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection."
format Artículos de Publicaciones Periódicas
publishedVersion
author Forcato, Cecilia
Klinzing, Jens G.
Carbone, Julia
Radloff, Michael
Weber, Frederik D.
Born, Jan
Diekelmann, Susanne
author_facet Forcato, Cecilia
Klinzing, Jens G.
Carbone, Julia
Radloff, Michael
Weber, Frederik D.
Born, Jan
Diekelmann, Susanne
author_sort Forcato, Cecilia
title Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_short Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_full Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_fullStr Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_full_unstemmed Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_sort reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/3244
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