Lipid electropore stabilization

"The stabilization of pores can be studied by different approaches such as simulations in silico or experimental procedures in vivo or in vitro. The energy to open a pore in a lipid membrane can be delivered by different external stimuli. To disrupt the membrane and initiate the pore opening, t...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fernández, María Laura, Risk, Marcelo
Formato: Capítulos de libro acceptedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
DINAMICA MOLECULAR
ELECTROPORACION
LIPIDOS
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/1741
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-1741
record_format dspace
spelling I32-R138-123456789-17412022-12-07T13:14:59Z Lipid electropore stabilization Fernández, María Laura Risk, Marcelo DINAMICA MOLECULAR ELECTROPORACION LIPIDOS "The stabilization of pores can be studied by different approaches such as simulations in silico or experimental procedures in vivo or in vitro. The energy to open a pore in a lipid membrane can be delivered by different external stimuli. To disrupt the membrane and initiate the pore opening, this energy has to reach a threshold. Then, once the pore is open, the external stimulus can be modulated to maintain the pore stable in time. This chapter first describes the basics of electropermeabilization, a process also called electroporation, and the basics of molecular dynamics in electropermeabilization. The chapter then describes in detail the molecular changes that lead to the pore opening and evolution by molecular dynamics. The chapter focuses on molecular dynamics because this technique allows the study of pore stabilization at molecular level, the interpretation of the lipid and water molecule rearrangements that are behind this phenomenon, and the visualization of the pore at the scale of size and time, in the order of nanometers and nanoseconds, respectively. Finally, the chapter also describes other approaches where pores remain open or the permeabilized state remains stable for a period of time, such as continuum modeling, experiments in planar membranes, and experiments in cells. The objective of this selection is to relate the results obtained by molecular dynamics with those obtained experimentally, or by other types of modeling, aiming to connect the mechanisms of pore stabilization by molecular dynamics at different scales." 2019-08-28T18:15:36Z 2019-08-28T18:15:36Z 2017-08 Capítulos de libro info:eu-repo/semantics/acceptedVersion 978-3319-32-885-0 http://ri.itba.edu.ar/handle/123456789/1741 en info:eu-repo/semantics/altIdentifier/doi/10.1007/978-3-319-32886-7_83 info:eu-repo/grantAgreement/CONICET/PIP GI/11220110100379/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/UBA/UBACyT/GC/20620130100027BA/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ITBA/ITBACyT/2015/AR. Ciudad Autónoma de Buenos Aires application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic DINAMICA MOLECULAR
ELECTROPORACION
LIPIDOS
spellingShingle DINAMICA MOLECULAR
ELECTROPORACION
LIPIDOS
Fernández, María Laura
Risk, Marcelo
Lipid electropore stabilization
topic_facet DINAMICA MOLECULAR
ELECTROPORACION
LIPIDOS
description "The stabilization of pores can be studied by different approaches such as simulations in silico or experimental procedures in vivo or in vitro. The energy to open a pore in a lipid membrane can be delivered by different external stimuli. To disrupt the membrane and initiate the pore opening, this energy has to reach a threshold. Then, once the pore is open, the external stimulus can be modulated to maintain the pore stable in time. This chapter first describes the basics of electropermeabilization, a process also called electroporation, and the basics of molecular dynamics in electropermeabilization. The chapter then describes in detail the molecular changes that lead to the pore opening and evolution by molecular dynamics. The chapter focuses on molecular dynamics because this technique allows the study of pore stabilization at molecular level, the interpretation of the lipid and water molecule rearrangements that are behind this phenomenon, and the visualization of the pore at the scale of size and time, in the order of nanometers and nanoseconds, respectively. Finally, the chapter also describes other approaches where pores remain open or the permeabilized state remains stable for a period of time, such as continuum modeling, experiments in planar membranes, and experiments in cells. The objective of this selection is to relate the results obtained by molecular dynamics with those obtained experimentally, or by other types of modeling, aiming to connect the mechanisms of pore stabilization by molecular dynamics at different scales."
format Capítulos de libro
acceptedVersion
author Fernández, María Laura
Risk, Marcelo
author_facet Fernández, María Laura
Risk, Marcelo
author_sort Fernández, María Laura
title Lipid electropore stabilization
title_short Lipid electropore stabilization
title_full Lipid electropore stabilization
title_fullStr Lipid electropore stabilization
title_full_unstemmed Lipid electropore stabilization
title_sort lipid electropore stabilization
publishDate 2019
url http://ri.itba.edu.ar/handle/123456789/1741
work_keys_str_mv AT fernandezmarialaura lipidelectroporestabilization
AT riskmarcelo lipidelectroporestabilization
_version_ 1765660715892342784

Ejemplares similares