Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone

Mostrar todas las versiones(3)

3α-Hydroxy-2,19-oxido-5αH-pregnan-20-one was synthesized in 6 steps from the easily available 19-hydroxypregnenolone 3-acetate. The 2,19-oxido bridge was formed in a single step upon spontaneous cyclization and desilylation of a TBDMS protected 19-hydroxy-2α,3α-epoxypregnane. The 4,19-oxido analogue...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eduardo, S.L., Ghini, A.A., Burton, G.
Formato:	Artículo publishedVersion
Publicado:	2003
Materias:	2,19-Oxido-allopregnanolone 4,19-oxido-allopregnanolone Neurosteroid Oxido-bridged steroid 19 hydroxy 2alpha,3alpha epoxypregnane 19 hydroxypregnenolone 3 acetate 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one 3alpha hydroxy 5alphah pregnan 20 one 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one bridged compound neurosteroid silane derivative unclassified drug article cyclization desilylation drug structure drug synthesis structure activity relation
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p468_Eduardo http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_14246376_v2003_n10_p468_Eduardo_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_14246376_v2003_n10_p468_Eduardo_oai
record_format	dspace
spelling	I28-R145-paper_14246376_v2003_n10_p468_Eduardo_oai2020-10-19 Eduardo, S.L. Ghini, A.A. Burton, G. 2003 3α-Hydroxy-2,19-oxido-5αH-pregnan-20-one was synthesized in 6 steps from the easily available 19-hydroxypregnenolone 3-acetate. The 2,19-oxido bridge was formed in a single step upon spontaneous cyclization and desilylation of a TBDMS protected 19-hydroxy-2α,3α-epoxypregnane. The 4,19-oxido analogue was obtained as a byproduct upon cyclization of the isomeric 3α,4α-epoxide. Fil:Ghini, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p468_Eduardo info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Arkivoc 2003;2003(10):468-476 2,19-Oxido-allopregnanolone 4,19-oxido-allopregnanolone Neurosteroid Oxido-bridged steroid 19 hydroxy 2alpha,3alpha epoxypregnane 19 hydroxypregnenolone 3 acetate 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one 3alpha hydroxy 5alphah pregnan 20 one 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one bridged compound neurosteroid silane derivative unclassified drug article cyclization desilylation drug structure drug synthesis structure activity relation Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_14246376_v2003_n10_p468_Eduardo_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	2,19-Oxido-allopregnanolone 4,19-oxido-allopregnanolone Neurosteroid Oxido-bridged steroid 19 hydroxy 2alpha,3alpha epoxypregnane 19 hydroxypregnenolone 3 acetate 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one 3alpha hydroxy 5alphah pregnan 20 one 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one bridged compound neurosteroid silane derivative unclassified drug article cyclization desilylation drug structure drug synthesis structure activity relation
spellingShingle	2,19-Oxido-allopregnanolone 4,19-oxido-allopregnanolone Neurosteroid Oxido-bridged steroid 19 hydroxy 2alpha,3alpha epoxypregnane 19 hydroxypregnenolone 3 acetate 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one 3alpha hydroxy 5alphah pregnan 20 one 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one bridged compound neurosteroid silane derivative unclassified drug article cyclization desilylation drug structure drug synthesis structure activity relation Eduardo, S.L. Ghini, A.A. Burton, G. Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone
topic_facet	2,19-Oxido-allopregnanolone 4,19-oxido-allopregnanolone Neurosteroid Oxido-bridged steroid 19 hydroxy 2alpha,3alpha epoxypregnane 19 hydroxypregnenolone 3 acetate 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one 3alpha hydroxy 5alphah pregnan 20 one 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one bridged compound neurosteroid silane derivative unclassified drug article cyclization desilylation drug structure drug synthesis structure activity relation
description	3α-Hydroxy-2,19-oxido-5αH-pregnan-20-one was synthesized in 6 steps from the easily available 19-hydroxypregnenolone 3-acetate. The 2,19-oxido bridge was formed in a single step upon spontaneous cyclization and desilylation of a TBDMS protected 19-hydroxy-2α,3α-epoxypregnane. The 4,19-oxido analogue was obtained as a byproduct upon cyclization of the isomeric 3α,4α-epoxide.
format	Artículo Artículo publishedVersion
author	Eduardo, S.L. Ghini, A.A. Burton, G.
author_facet	Eduardo, S.L. Ghini, A.A. Burton, G.
author_sort	Eduardo, S.L.
title	Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone
title_short	Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone
title_full	Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone
title_fullStr	Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone
title_full_unstemmed	Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone
title_sort	oxido-bridged neurosteroid analogues. synthesis of 2,19-oxido-allopregnanolone
publishDate	2003
url	http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p468_Eduardo http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_14246376_v2003_n10_p468_Eduardo_oai
work_keys_str_mv	AT eduardosl oxidobridgedneurosteroidanaloguessynthesisof219oxidoallopregnanolone AT ghiniaa oxidobridgedneurosteroidanaloguessynthesisof219oxidoallopregnanolone AT burtong oxidobridgedneurosteroidanaloguessynthesisof219oxidoallopregnanolone
_version_	1766026767690104832

Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone

Ejemplares similares