PKMζ inactivation induces spatial familiarity

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Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated...

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Autores principales:	Moncada, D., Viola, H.
Formato:	Artículo publishedVersion
Publicado:	2008
Materias:	protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect gene expression regulation metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_10720502_v15_n11_p810_Moncada_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_10720502_v15_n11_p810_Moncada_oai
record_format	dspace
spelling	I28-R145-paper_10720502_v15_n11_p810_Moncada_oai2020-10-19 Moncada, D. Viola, H. 2008 Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Learn. Mem. 2008;15(11):810-814 protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors PKMζ inactivation induces spatial familiarity info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_10720502_v15_n11_p810_Moncada_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors
spellingShingle	protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors Moncada, D. Viola, H. PKMζ inactivation induces spatial familiarity
topic_facet	protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors
description	Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press.
format	Artículo Artículo publishedVersion
author	Moncada, D. Viola, H.
author_facet	Moncada, D. Viola, H.
author_sort	Moncada, D.
title	PKMζ inactivation induces spatial familiarity
title_short	PKMζ inactivation induces spatial familiarity
title_full	PKMζ inactivation induces spatial familiarity
title_fullStr	PKMζ inactivation induces spatial familiarity
title_full_unstemmed	PKMζ inactivation induces spatial familiarity
title_sort	pkmζ inactivation induces spatial familiarity
publishDate	2008
url	http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_10720502_v15_n11_p810_Moncada_oai
work_keys_str_mv	AT moncadad pkmzinactivationinducesspatialfamiliarity AT violah pkmzinactivationinducesspatialfamiliarity
_version_	1766026746996457472

PKMζ inactivation induces spatial familiarity

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