Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation

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Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can se...

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Autores principales:	Moncada, D., Ballarini, F., Martinez, M.C., Frey, J.U., Viola, H.
Formato:	Artículo publishedVersion
Publicado:	2011
Materias:	CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v108_n31_p12931_Moncada_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_00278424_v108_n31_p12931_Moncada_oai
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spelling	I28-R145-paper_00278424_v108_n31_p12931_Moncada_oai2024-08-16 Moncada, D. Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H. 2011 Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Proc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936 CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v108_n31_p12931_Moncada_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus
spellingShingle	CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus Moncada, D. Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H. Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
topic_facet	CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus
description	Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
format	Artículo Artículo publishedVersion
author	Moncada, D. Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H.
author_facet	Moncada, D. Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H.
author_sort	Moncada, D.
title	Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_short	Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_full	Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_fullStr	Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_full_unstemmed	Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_sort	identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
publishDate	2011
url	http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v108_n31_p12931_Moncada_oai
work_keys_str_mv	AT moncadad identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation AT ballarinif identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation AT martinezmc identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation AT freyju identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation AT violah identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation
_version_	1809356888918196224

Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation

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