Biomarcadores moleculares en mastitis bovina

Mastitis is an inflammation of the mammary gland generally caused by a bacterial infection. It is the disease that has the highest morbidity and mortality within dairy herds, affecting milk production and the profitability of the dairy farms. Besides, if the process is severe or prolonged, it often...

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Autores principales:	Caggiano, N., De Simone, E.
Formato:	Artículo publishedVersion
Lenguaje:	Español
Publicado:	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias 2021
Materias:	mastitis biomarcadores diagnóstico MMPs GAGs biomarkers diagnosis
Acceso en línea:	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_6778 http://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_6778.dir/6778.PDF
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
language	Español
orig_language_str_mv	spa
topic	mastitis biomarcadores diagnóstico MMPs GAGs mastitis biomarkers diagnosis MMPs GAGs
spellingShingle	mastitis biomarcadores diagnóstico MMPs GAGs mastitis biomarkers diagnosis MMPs GAGs Caggiano, N. De Simone, E. Biomarcadores moleculares en mastitis bovina
topic_facet	mastitis biomarcadores diagnóstico MMPs GAGs mastitis biomarkers diagnosis MMPs GAGs
description	Mastitis is an inflammation of the mammary gland generally caused by a bacterial infection. It is the disease that has the highest morbidity and mortality within dairy herds, affecting milk production and the profitability of the dairy farms. Besides, if the process is severe or prolonged, it often causes irreversible damage to the mammary gland. In addition to the somatic cell count and profile protein analysis, the evaluation of molecular markers related to inflammation is of interest for the early diagnosis, control and prognosis of the disease. Molecular markers such as metalloproteinases (MMPs), lactate dehydrogenase (LDH), N-Acetyl-ß-D-Glucosaminidase (NAGase), Beta glucuronidase, and glycosaminoglycans (GAGs) are also related to udder disease. Some biomarkers involve proteases that degrade the extracellular matrix, such as metalloproteinases 2 and 9, among others. These proteases are physiologically responsible for the normal remodeling of the extracellular matrix. However, proteases play a preponderant role in the pathophysiology of mastitic processes, especially in their recurrent presentation, with the inhibition of MMPs being an interesting therapeutic proposal. The enzymes LDH, NAGase and beta glucuronidase are indicators of inflammation, since the increase in their activity is associated with leukocyte lysosomal granules. GAGs are constituents of the extracellular matrix and could be used as indicators of mammary health, because they remain constant in milk throughout the productive process of healthy animals and rise in light of mild pathological processes. The analysis and monitoring of markers in dairy cattle could be an important complement to conventional tests for the diagnosis and monitoring of the health of the mammary gland.
format	Artículo Artículo publishedVersion
author	Caggiano, N. De Simone, E.
author_facet	Caggiano, N. De Simone, E.
author_sort	Caggiano, N.
title	Biomarcadores moleculares en mastitis bovina
title_short	Biomarcadores moleculares en mastitis bovina
title_full	Biomarcadores moleculares en mastitis bovina
title_fullStr	Biomarcadores moleculares en mastitis bovina
title_full_unstemmed	Biomarcadores moleculares en mastitis bovina
title_sort	biomarcadores moleculares en mastitis bovina
publisher	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias
publishDate	2021
url	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_6778 http://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_6778.dir/6778.PDF
work_keys_str_mv	AT caggianon biomarcadoresmolecularesenmastitisbovina AT desimonee biomarcadoresmolecularesenmastitisbovina AT caggianon molecularbiomarkersinbovinemastitis AT desimonee molecularbiomarkersinbovinemastitis
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spelling	I28-R145-HWA_67782023-06-15 Mastitis is an inflammation of the mammary gland generally caused by a bacterial infection. It is the disease that has the highest morbidity and mortality within dairy herds, affecting milk production and the profitability of the dairy farms. Besides, if the process is severe or prolonged, it often causes irreversible damage to the mammary gland. In addition to the somatic cell count and profile protein analysis, the evaluation of molecular markers related to inflammation is of interest for the early diagnosis, control and prognosis of the disease. Molecular markers such as metalloproteinases (MMPs), lactate dehydrogenase (LDH), N-Acetyl-ß-D-Glucosaminidase (NAGase), Beta glucuronidase, and glycosaminoglycans (GAGs) are also related to udder disease. Some biomarkers involve proteases that degrade the extracellular matrix, such as metalloproteinases 2 and 9, among others. These proteases are physiologically responsible for the normal remodeling of the extracellular matrix. However, proteases play a preponderant role in the pathophysiology of mastitic processes, especially in their recurrent presentation, with the inhibition of MMPs being an interesting therapeutic proposal. The enzymes LDH, NAGase and beta glucuronidase are indicators of inflammation, since the increase in their activity is associated with leukocyte lysosomal granules. GAGs are constituents of the extracellular matrix and could be used as indicators of mammary health, because they remain constant in milk throughout the productive process of healthy animals and rise in light of mild pathological processes. The analysis and monitoring of markers in dairy cattle could be an important complement to conventional tests for the diagnosis and monitoring of the health of the mammary gland. Fil: Caggiano, N. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Fisiología Animal. Buenos Aires, Argentina Fil: De Simone, E. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Fisiología Animal. Buenos Aires, Argentina Caggiano, N. De Simone, E. 2021 La mastitis es la inflamación de la glándula mamaria, generalmente derivada de una infección microbiana. Es la patología con mayor morbilidad y mortalidad dentro de los rodeos lecheros, afectando la producción láctea y la rentabilidad de los tambos. Además, si el proceso es muy grave o perdura en el tiempo genera daños muchas veces irreversibles en la glándula mamaria. Es por eso que, además del recuento de células somáticas, y el análisis del perfil proteico, la evaluación de marcadores moleculares relacionados con la inflamación resulta de interés para el diagnóstico temprano, control y pronóstico de la enfermedad. Marcadores moleculares como las metaloproteasas (MMPs), lactato deshidrogenasa (LDH), N-Acetil-ß-D-Glucosaminidasa (NAGasa), Beta glucuronidasa y los glicosaminoglicanos (GAGs) también se encuentran relacionados con la enfermedad mamaria. Algunos biomarcadores involucran proteasas que degradan la matriz extracelular como pueden ser las metaloproteasas 2 y 9 entre otras. Estas proteasas fisiológicamente están encargadas del normal remodelado de la matriz extracelular. Sin embargo, las proteasas juegan un rol preponderante en la fisiopatología de los procesos mastíticos, especialmente en su presentación recidivante, siendo la inhibición de las MMPs una propuesta terapéutica interesante. Las enzimas LDH, NAGasa y beta glucuronidasa son indicadores de inflamación dado que el incremento de su actividad se asocia con gránulos de lisosomales de leucocitos. Los GAGs son constituyentes de la matriz extracelular y podrían utilizarse como indicadores de sanidad mamaria, porque se mantienen constantes en leche a lo largo del proceso productivo de los animales sanos y se elevan ante procesos patológicos leves. El análisis y seguimiento de marcadores en vacas lecheras podrían ser un complemento importante de las pruebas convencionales para el diagnóstico y seguimiento de la sanidad de la glándula mamaria. application/pdf ISSN 1668-3498 (en línea) mastitis biomarcadores diagnóstico MMPs GAGs mastitis biomarkers diagnosis MMPs GAGs spa Universidad de Buenos Aires. Facultad de Ciencias Veterinarias info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ InVet, vol. 23, nº2 Biomarcadores moleculares en mastitis bovina Molecular biomarkers in bovine mastitis info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_6778 http://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_6778.dir/6778.PDF

Biomarcadores moleculares en mastitis bovina

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