InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal...
To evaluate the effects of the cadmium (Cd) administration at different gestation times, 24 rats were mated under standard rearing conditions. After pregnancy confirmation, rats were randomly assigned to 4 treatment groups. Experimental groups received a subcutaneous dose of 10 mg Cd per kg of body...
| Autores principales: | , , , , |
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| Formato: | Artículo publishedVersion |
| Lenguaje: | Español |
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Universidad de Buenos Aires. Facultad de Ciencias Veterinarias.
2012
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3811 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3811.dir/3811.PDF |
| Aporte de: |
| id |
I28-R145-HWA_3811 |
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| record_format |
dspace |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
Ratas Cadmio toxicidad Organos maternos Preñez Fetos Rats Cadmium toxicity Maternal organs Pregnancy Fetuses |
| spellingShingle |
Ratas Cadmio toxicidad Organos maternos Preñez Fetos Rats Cadmium toxicity Maternal organs Pregnancy Fetuses Díaz, M. Quiroga, M.A. Landa, R. Giordano, A. Najle, R. InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... |
| topic_facet |
Ratas Cadmio toxicidad Organos maternos Preñez Fetos Rats Cadmium toxicity Maternal organs Pregnancy Fetuses |
| description |
To evaluate the effects of the cadmium (Cd) administration at different gestation times, 24 rats were mated under standard rearing conditions. After pregnancy confirmation, rats were randomly assigned to 4 treatment groups. Experimental groups received a subcutaneous dose of 10 mg Cd per kg of body weight at the day: 7 Group I(GI); 9 Group II(GII) and 11 Group III(GIII) of pregnancy. The control group (Group IV- GIV) received an equivalent volume of saline solution. On day 20 post-conception, all rats were sacrificed. Samples of liver, kidney, spleen, lung, placenta and fetuses were collected to determine Cd concentration and for histological studies. The results were analyzed statistically (ANOVA and Student?s t test). In the organs and fetuses of rats from GI; GII and GIII, Cd concentrations were significantly higher than in the control (P<0.05). In Cd-treated groups, were observed: kidneys with picnotic nuclei in tubules of the renal cortex; liver with multifocal leukocytic infiltrate, cellular vacuolization in the centrolobular zone; lungs with atelectasis and alveolar emphysema; placentas with picnotic nuclei, fibrinoid deposits and infiltration of granulocytes. Bone lesions were observed in fetuses, such as limb, tail and skull bones agenesis. |
| format |
Artículo Artículo publishedVersion |
| author |
Díaz, M. Quiroga, M.A. Landa, R. Giordano, A. Najle, R. |
| author_facet |
Díaz, M. Quiroga, M.A. Landa, R. Giordano, A. Najle, R. |
| author_sort |
Díaz, M. |
| title |
InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... |
| title_short |
InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... |
| title_full |
InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... |
| title_fullStr |
InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... |
| title_full_unstemmed |
InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... |
| title_sort |
invet. 2012, 14(2): 209-220 issn 1514-6634 (impreso) cadmium on maternal... |
| publisher |
Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. |
| publishDate |
2012 |
| url |
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3811 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3811.dir/3811.PDF |
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1824359796094009344 |
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I28-R145-HWA_38112024-11-05 InVet. 2012, 14(2): 209-220 ISSN 1514-6634 (impreso) Cadmium on maternal... To evaluate the effects of the cadmium (Cd) administration at different gestation times, 24 rats were mated under standard rearing conditions. After pregnancy confirmation, rats were randomly assigned to 4 treatment groups. Experimental groups received a subcutaneous dose of 10 mg Cd per kg of body weight at the day: 7 Group I(GI); 9 Group II(GII) and 11 Group III(GIII) of pregnancy. The control group (Group IV- GIV) received an equivalent volume of saline solution. On day 20 post-conception, all rats were sacrificed. Samples of liver, kidney, spleen, lung, placenta and fetuses were collected to determine Cd concentration and for histological studies. The results were analyzed statistically (ANOVA and Student?s t test). In the organs and fetuses of rats from GI; GII and GIII, Cd concentrations were significantly higher than in the control (P<0.05). In Cd-treated groups, were observed: kidneys with picnotic nuclei in tubules of the renal cortex; liver with multifocal leukocytic infiltrate, cellular vacuolization in the centrolobular zone; lungs with atelectasis and alveolar emphysema; placentas with picnotic nuclei, fibrinoid deposits and infiltration of granulocytes. Bone lesions were observed in fetuses, such as limb, tail and skull bones agenesis. Fil: Díaz, M. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Ciencias Biológicas. Tandil, Argentina Fil: Quiroga, M.A. CONICET. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil (CIVETAN). Tandil, Argentina Fil: Quiroga, M.A. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Tandil, Argentina Fil: Landa, R. CONICET. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil (CIVETAN). Tandil, Argentina Fil: Landa, R. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Tandil, Argentina Fil: Giordano, A. CONICET. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil (CIVETAN). Tandil, Argentina Fil: Giordano, A. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Tandil, Argentina Fil: Najle, R. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Ciencias Biológicas. Tandil, Argentina Díaz, M. Quiroga, M.A. Landa, R. Giordano, A. Najle, R. 2012 Para evaluar los efectos de la administración de cadmio (Cd) a diferentes tiempos de gestación, 24 ratas fueron preñadas bajo condiciones estandarizadas de crianza. Confirmada la preñez, las ratas fueron asignadas al azar a 4 tratamientos, que recibieron una dosis subcutánea de 10 mg Cd por kg PV a los días 7(GI); 9(GII) y 11(GIII) de preñez; o una dosis equivalente de solución fisiológica (GIV ? control). El día 20 posconcepción, todas las ratas fueron sacrificadas. Se obtuvieron muestras de hígado, riñón, bazo, pulmón, fetos y placenta, para determinar la concentración tisular de Cd y para estudios histológicos. Los resultados fueron analizados estadísticamente (ANOVA y test t de Student). En los órganos de ratas de los grupos GI, GII and GIII, las concentraciones de Cd fueron significativamente más elevadas que en el control (p<0.05). En los grupos tratados con Cd, se observaron riñones con núcleos picnóticos en los túbulos de la corteza renal; hígado con infiltrado leucocítico multifocal, vacuolización celular en la zona centrolobulillar y cuerpos apoptóticos. En las placentas, se determinaron núcleos picnóticos, depósitos fibrinoides e infiltración de granulocitos. Se observó agenesia de extremidades, cola y cráneo en los fetos. application/pdf 1514-6634 (impreso) 1668-3498 (en línea) Ratas Cadmio toxicidad Organos maternos Preñez Fetos Rats Cadmium toxicity Maternal organs Pregnancy Fetuses spa Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ InVet, vol. 14, nº2 Efecto del cadmio en órganos maternos de ratas y fetos en diferentes tiempos de gestación Effect of cadmium on maternal organs of rats and fetuses at different times of gestation info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3811 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3811.dir/3811.PDF |