Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular

Cardiovascular disease (CVD) is the leading cause of death in the West; obesity, especially abdominal (AO) and the inflammatory condition is associated with the presence of CVD and insulin resistance (IR). Adiponectin, considered an insulin sensitizer has anti-atherogenic and anti-inflammatory effec...

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Autor principal: Bonneau, Graciela Alicia
Otros Autores: Castillo Rascon, María Susana
Formato: Tesis doctoral acceptedVersion
Lenguaje:Español
Publicado: Facultad de Farmacia y Bioquímica 2015
Materias:
Factores de riesgo
Insulino resistencia
Adiponectina
Ciencia de la vida
Acceso en línea:http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1160
http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1160.dir/1160.PDF
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-HWA_1160
record_format dspace
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
language Español
orig_language_str_mv spa
topic Factores de riesgo
Insulino resistencia
Adiponectina
Ciencia de la vida
spellingShingle Factores de riesgo
Insulino resistencia
Adiponectina
Ciencia de la vida
Bonneau, Graciela Alicia
Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
topic_facet Factores de riesgo
Insulino resistencia
Adiponectina
Ciencia de la vida
description Cardiovascular disease (CVD) is the leading cause of death in the West; obesity, especially abdominal (AO) and the inflammatory condition is associated with the presence of CVD and insulin resistance (IR). Adiponectin, considered an insulin sensitizer has anti-atherogenic and anti-inflammatory effects. The relationship between the presence of IR and risk factors associated with morbidity and mortality from CVD by a prospective cohort was studied. 315 individuals (247 females (47.6 ± 9.1 years) and 68 males (47.1 ± 9.2 years)) were studied for five years. A subgroup of 70 subjects for the study of gene and adiponectin receptors for molecular biology included. Prevalence of overweight (38.7%) and obesity (27.3%) associated with an atherogenic lipid profile was found. 24.1% of individuals had metabolic syndrome (MS) being col-HDL decreased the most common parameter; according HOMA IR was 18%. Obesity increased from 2007 to 2011 by 8.1%. Over 5 years, 58 individuals developed diabetes and 9 IR (type 2 diabetes mellitus). Of the variables analyzed, AO predicted IR and obesity predicted T2DM. 45.7% of individuals had decreased adiponectin. Only in women serum adiponectin explained the IR independently. In the analysis of gene sequences ADIPOQ a SNP found not described in the SNP database (dbSNP) at -11 348 G> T position of the promoter region at a frequency of 38% was associated with lower values of circulating adiponectin. The GG genotype of ADIPOR2 SNP rs1029629 showed significant association with IR and with decreased circulating adiponectin.
author2 Castillo Rascon, María Susana
author_facet Castillo Rascon, María Susana
Bonneau, Graciela Alicia
format Tesis doctoral
Tesis doctoral
acceptedVersion
author Bonneau, Graciela Alicia
author_sort Bonneau, Graciela Alicia
title Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
title_short Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
title_full Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
title_fullStr Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
title_full_unstemmed Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
title_sort estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
publisher Facultad de Farmacia y Bioquímica
publishDate 2015
url http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1160
http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1160.dir/1160.PDF
work_keys_str_mv AT bonneaugracielaalicia estudioprospectivodefactoresderiesgoasociadosainsulinoresistenciayaldesarrollodeenfermedadcardiovascular
_version_ 1766017457728782336
spelling I28-R145-HWA_11602019-09-25 Cardiovascular disease (CVD) is the leading cause of death in the West; obesity, especially abdominal (AO) and the inflammatory condition is associated with the presence of CVD and insulin resistance (IR). Adiponectin, considered an insulin sensitizer has anti-atherogenic and anti-inflammatory effects. The relationship between the presence of IR and risk factors associated with morbidity and mortality from CVD by a prospective cohort was studied. 315 individuals (247 females (47.6 ± 9.1 years) and 68 males (47.1 ± 9.2 years)) were studied for five years. A subgroup of 70 subjects for the study of gene and adiponectin receptors for molecular biology included. Prevalence of overweight (38.7%) and obesity (27.3%) associated with an atherogenic lipid profile was found. 24.1% of individuals had metabolic syndrome (MS) being col-HDL decreased the most common parameter; according HOMA IR was 18%. Obesity increased from 2007 to 2011 by 8.1%. Over 5 years, 58 individuals developed diabetes and 9 IR (type 2 diabetes mellitus). Of the variables analyzed, AO predicted IR and obesity predicted T2DM. 45.7% of individuals had decreased adiponectin. Only in women serum adiponectin explained the IR independently. In the analysis of gene sequences ADIPOQ a SNP found not described in the SNP database (dbSNP) at -11 348 G> T position of the promoter region at a frequency of 38% was associated with lower values of circulating adiponectin. The GG genotype of ADIPOR2 SNP rs1029629 showed significant association with IR and with decreased circulating adiponectin. Fil: Bonneau, Graciela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Castillo Rascon, María Susana Facultad de Farmacia y Bioquímica Berg, Gabriela Bonneau, Graciela Alicia 2015-11-05 La enfermedad cardiovascular (ECV) representa la primera causa de muerte en occidente; la obesidad, especialmente abdominal (OA) y el estado inflamatorio se asocian con la presencia de ECV e insulino-resistencia (IR). La adiponectina, considerada un sensibilizador de insulina tiene efectos anti-aterogénicas y anti-inflamatorios. Se estudió la relación entre la presencia de IR y factores de riesgo asociados, con la morbi-mortalidad por ECV mediante un estudio de cohorte prospectivo. Se estudiaron 315 individuos (247 mujeres (47,6 ± 9,1 años) y 68 varones (47,1 ± 9,2 años)) durante 5 años. Se incluyó un subgrupo de 70 individuos para el estudio de gen y receptores de adiponectina por biología molecular. Se encontró un predominio de sobrepeso (38,7%) y obesidad (27,3%) asociado a un perfil lipídico aterogénico. El 24,1% de los individuos tenía Síndrome Metabólico (SM) siendo col-HDL disminuido el parámetro más frecuente; según HOMA El 18% era IR. La obesidad aumento del 2007 al 2011 en un 8,1%. A lo largo de los 5 años, 58 individuos desarrollaron IR y 9 diabetes (DBT2). De las variables analizadas, OA predijo IR y obesidad DBT2. El 45,7% de los individuos, tenían adiponectina disminuida. Solo en mujeres la concentración sérica de adiponectina explicó la IR de forma independiente. En el análisis de las secuencias de genes ADIPOQ se encontró un SNP no descripto en la base de datos de SNPs (dbSNP) en la posición -11348 G>T de la región promotora en una frecuencia de 38% que se asoció con valores disminuidos de adiponectina circulante. El genotipo GG del SNP rs1029629 del ADIPOR2 presentó asociación significativa con IR y con disminución de adiponectina circulante. application/pdf Negri, Gustavo Lucentini, Marcelo Rodriguez, Manuel Factores de riesgo Insulino resistencia Adiponectina spa Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Ciencia de la vida Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular info:eu-repo/semantics/doctoralThesis info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1160 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1160.dir/1160.PDF

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