Design of an integrated circuit with buried double junction photodiodes for optical immunoassays

Optical immunoassays require measurement systems capable of distinguishing the light from the laser source, used to illuminate the assay, from the light generated by the particles contained within the assay itself (fluorescence). The main challenge is that the light used to excite the sample is seve...

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Autores principales: Goyret, Juan Pablo, Molina Abeniacar, Segundo
Formato: Artículo publishedVersion
Lenguaje:Español
Publicado: FIUBA 2020
Materias:
immunoassays
photodiodes
Point-of-Care
CMOS
inmunoensayos
fotodiodos
point-of-care
Acceso en línea:https://elektron.fi.uba.ar/elektron/article/view/103
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=elektron&d=103_oai
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Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-103_oai
record_format dspace
spelling I28-R145-103_oai2026-02-11 Goyret, Juan Pablo Molina Abeniacar, Segundo 2020-12-14 Optical immunoassays require measurement systems capable of distinguishing the light from the laser source, used to illuminate the assay, from the light generated by the particles contained within the assay itself (fluorescence). The main challenge is that the light used to excite the sample is several orders of magnitude more intense than that generated by fluorescence. Usually, single junction photodiodes and optical filters are used. The sensitivity of these schemes is limited by the filter performance. In this work, the design of a CMOS integrated circuit including buried double junction photodiodes (BDJ) is presented. This approach allows the measurement of both light sources simultaneously. From simulations, it is shown that this integrated circuit with BDJ would achieve a better detection limit than the scheme based on single-junction photodiodes of equivalent silicon area.  Furthermore, integrating the photodetectors and the reading circuit on the same chip would make the system suitable to be used in biomedical applications such as Point-of-Care (POC) devices. Los inmunoensayos ópticos requieren de sistemas de medición capaces de distinguir la luz de la fuente láser, utilizada para iluminar el ensayo, de aquella generada por las partículas contenidas en el mismo (fluorescencia). El principal desafío es que la luz usada para excitar la muestra es varios órdenes de magnitud más intensa que la generada por fluorescencia. Usualmente, se utilizan filtros ópticos y fotodiodos de juntura simple. La sensibilidad de estos esquemas se encuentra limitada por el desempeño del filtro. En este trabajo se presenta el diseño de un circuito integrado de lectura que incorpora fotodiodos de doble juntura, lo que permite la medición de ambas fuentes de luz en simultáneo. A partir de simulaciones, se demuestra que este enfoque lograría un mejor límite de detección que el esquema basado en fotodiodos de juntura simple de igual área. Además, la integración del circuito de lectura y los fotoreceptores en un mismo chip, favorecería la miniaturización y portabilidad del sistema para aplicaciones biomédicas como en dispositivos Point-of-Care (POC). application/pdf text/html https://elektron.fi.uba.ar/elektron/article/view/103 10.37537/rev.elektron.4.2.103.2020 spa FIUBA https://elektron.fi.uba.ar/elektron/article/view/103/223 https://elektron.fi.uba.ar/elektron/article/view/103/221 Derechos de autor 2020 Juan Pablo Goyret, Segundo Molina Abeniacar Elektron Journal; Vol. 4 No. 2 (2020); 114-125 Revista Elektron; Vol. 4 Núm. 2 (2020); 114-125 Revista Elektron; v. 4 n. 2 (2020); 114-125 2525-0159 2525-0159 immunoassays photodiodes Point-of-Care CMOS inmunoensayos fotodiodos point-of-care CMOS Design of an integrated circuit with buried double junction photodiodes for optical immunoassays Diseño de un circuito integrado con fotodiodos de doble juntura para inmunoensayos ópticos info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=elektron&d=103_oai
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
language Español
orig_language_str_mv spa
topic immunoassays
photodiodes
Point-of-Care
CMOS
inmunoensayos
fotodiodos
point-of-care
CMOS
spellingShingle immunoassays
photodiodes
Point-of-Care
CMOS
inmunoensayos
fotodiodos
point-of-care
CMOS
Goyret, Juan Pablo
Molina Abeniacar, Segundo
Design of an integrated circuit with buried double junction photodiodes for optical immunoassays
topic_facet immunoassays
photodiodes
Point-of-Care
CMOS
inmunoensayos
fotodiodos
point-of-care
CMOS
description Optical immunoassays require measurement systems capable of distinguishing the light from the laser source, used to illuminate the assay, from the light generated by the particles contained within the assay itself (fluorescence). The main challenge is that the light used to excite the sample is several orders of magnitude more intense than that generated by fluorescence. Usually, single junction photodiodes and optical filters are used. The sensitivity of these schemes is limited by the filter performance. In this work, the design of a CMOS integrated circuit including buried double junction photodiodes (BDJ) is presented. This approach allows the measurement of both light sources simultaneously. From simulations, it is shown that this integrated circuit with BDJ would achieve a better detection limit than the scheme based on single-junction photodiodes of equivalent silicon area.  Furthermore, integrating the photodetectors and the reading circuit on the same chip would make the system suitable to be used in biomedical applications such as Point-of-Care (POC) devices.
format Artículo
publishedVersion
author Goyret, Juan Pablo
Molina Abeniacar, Segundo
author_facet Goyret, Juan Pablo
Molina Abeniacar, Segundo
author_sort Goyret, Juan Pablo
title Design of an integrated circuit with buried double junction photodiodes for optical immunoassays
title_short Design of an integrated circuit with buried double junction photodiodes for optical immunoassays
title_full Design of an integrated circuit with buried double junction photodiodes for optical immunoassays
title_fullStr Design of an integrated circuit with buried double junction photodiodes for optical immunoassays
title_full_unstemmed Design of an integrated circuit with buried double junction photodiodes for optical immunoassays
title_sort design of an integrated circuit with buried double junction photodiodes for optical immunoassays
publisher FIUBA
publishDate 2020
url https://elektron.fi.uba.ar/elektron/article/view/103
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=elektron&d=103_oai
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AT goyretjuanpablo disenodeuncircuitointegradoconfotodiodosdedoblejunturaparainmunoensayosopticos
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