Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep

The current work evaluated the relationship between efficacy and pharmacokinetics of two commercial injectable formulations of ivermectin (IVM) in adult merino sheep artificially infested with Psoroptes ovis. Animals were treated subcutaneously with IVM 1% formulation (two doses on days 0 and 7) at...

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Autores principales: LARROZA, Marcela, SOLER, Paula, ROBLES, Carlos, CABRERA, Raúl, CANTON, Candela, LANUSSE, Carlos, LIFSCHITZ, Adrian Luis
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Litoral 2020
Acceso en línea:https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/9292
Aporte de:
Biblioteca Virtual - Publicaciones (UNL) de Universidad Nacional del Litoral
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institution Universidad Nacional del Litoral
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container_title_str Biblioteca Virtual - Publicaciones (UNL)
language Español
format Artículo revista
author LARROZA, Marcela
SOLER, Paula
ROBLES, Carlos
CABRERA, Raúl
CANTON, Candela
LANUSSE, Carlos
LIFSCHITZ, Adrian Luis
spellingShingle LARROZA, Marcela
SOLER, Paula
ROBLES, Carlos
CABRERA, Raúl
CANTON, Candela
LANUSSE, Carlos
LIFSCHITZ, Adrian Luis
Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep
author_facet LARROZA, Marcela
SOLER, Paula
ROBLES, Carlos
CABRERA, Raúl
CANTON, Candela
LANUSSE, Carlos
LIFSCHITZ, Adrian Luis
author_sort LARROZA, Marcela
title Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep
title_short Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep
title_full Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep
title_fullStr Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep
title_full_unstemmed Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep
title_sort failure of efficacy of two ivermectin formulations against psoroptes ovis (hering, 1838) in sheep
description The current work evaluated the relationship between efficacy and pharmacokinetics of two commercial injectable formulations of ivermectin (IVM) in adult merino sheep artificially infested with Psoroptes ovis. Animals were treated subcutaneously with IVM 1% formulation (two doses on days 0 and 7) at 0.2 mg / kg or with a single dose of IVM 3.15% preparation at 1.05 mg / kg. Live mites were counted weekly by performing skin scrapings between days 0 and 28 post-treatment to determine the efficacy of each IVM formulation. Blood samples were taken up to 35 days post-treatment to measure IVM plasma concentrations. A significant decrease in mite counts was observed from day 14 post-treatment. However, live mites were found in all samples for both groups throughout the entire trial. After IVM 1% administration, the highest effcacy was observed  on day 28 (93.3%  whereas in the IVM 3,15% group was obtained on day 21 post treatment (95.9%).Higher IVM plasma concentrations were observed in animals treated with the IVM 3.15% formulation. Failure to obtain a parasitological cure after treatment with both IVM formulations may reflect the presence of resistant mites to this drug.
publisher Universidad Nacional del Litoral
publishDate 2020
url https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/9292
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first_indexed 2023-07-05T23:07:04Z
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spelling I26-R133-article-92922023-09-15T10:33:35Z Failure of efficacy of two ivermectin formulations against Psoroptes ovis (Hering, 1838) in sheep Falla en la eficacia de dos formulaciones de ivermectina contra Psoroptes ovis (Hering, 1838) en ovinos Falha na eficácia de duas formulações de ivermectina contra Psoroptes ovis (Hering, 1838) em ovinos LARROZA, Marcela SOLER, Paula ROBLES, Carlos CABRERA, Raúl CANTON, Candela LANUSSE, Carlos LIFSCHITZ, Adrian Luis The current work evaluated the relationship between efficacy and pharmacokinetics of two commercial injectable formulations of ivermectin (IVM) in adult merino sheep artificially infested with Psoroptes ovis. Animals were treated subcutaneously with IVM 1% formulation (two doses on days 0 and 7) at 0.2 mg / kg or with a single dose of IVM 3.15% preparation at 1.05 mg / kg. Live mites were counted weekly by performing skin scrapings between days 0 and 28 post-treatment to determine the efficacy of each IVM formulation. Blood samples were taken up to 35 days post-treatment to measure IVM plasma concentrations. A significant decrease in mite counts was observed from day 14 post-treatment. However, live mites were found in all samples for both groups throughout the entire trial. After IVM 1% administration, the highest effcacy was observed  on day 28 (93.3%  whereas in the IVM 3,15% group was obtained on day 21 post treatment (95.9%).Higher IVM plasma concentrations were observed in animals treated with the IVM 3.15% formulation. Failure to obtain a parasitological cure after treatment with both IVM formulations may reflect the presence of resistant mites to this drug. El presente trabajo evaluó la relación entre la eficacia y la farmacocinética de dos formulaciones comerciales inyectables de ivermectina (IVM) en ovinos merino adultos artificialmente infestados con Psoroptes ovis. Los animales fueron tratados por vía subcutánea con IVM 1 % en dos dosis con un intervalo de aplicación de 7 días, (0.2 mg/kg) o con una única dosis de IVM 3.15%, (1.05 mg/kg). Se realizaron conteos semanales de ácaros vivos mediante raspajes de piel entre el día 0 y 28 post-tratamiento para determinar la eficacia de los tratamientos, y se tomaron muestras de sangre para medir las concentraciones de IVM en plasma. Se observó una disminución significativa en los conteos de ácaros a partir del día 14 post-tratamiento, sin embargo, se encontraron ácaros vivos en todos los muestreos para ambos grupos. En el Grupo IVM 1%, la máxima eficacia se observó el día 28 post tratamiento (93.3%), mientras que en el Grupo IVM 3,15% este registro se obtuvo el día 21 (95.9%). Mayores concentraciones de IVM fueron observadas en los animales tratados con la formulación 3.15 %. La falla para obtener una cura parasitológica tras el tratamiento con ambas formulaciones de IVM puede ser indicativo de la presencia de ácaros resistentes a este principio activo. O presente trabalho avaliou a relação entre a eficácia e a farmacocinética de duas formulações injetáveis ​​comerciais de ivermectina (MIV) em ovelhas merino adultas infestadas artificialmente com Psoroptes ovis. Os animais foram tratados subcutaneamente com 1% de MIV em duas doses com um intervalo de aplicação de 7 dias (0,2 mg / kg) ou com uma dose única de 3,15% de MIV (1,05 mg / kg). As contagens semanais de ácaros vivos foram realizadas por raspagens na pele entre os dias 0 e 28 após o tratamento para determinar a eficácia dos tratamentos, e amostras de sangue foram coletadas para medir as concentrações plasmáticas de MIV. Uma diminuição significativa na contagem de ácaros foi observada a partir do dia 14 após o tratamento, no entanto, foram encontrados ácaros vivos em todas as amostras para ambos os grupos. No grupo IVM a 1%, a eficácia máxima foi observada no dia 28 após o tratamento (93,3%), enquanto no grupo IVM 3,15% esse registro foi obtido no dia 21 (95,9%). Maiores concentrações de MIV foram observadas em animais tratados com a formulação de 3,15%. A falha em obter uma cura parasitológica após o tratamento com ambas as formulações de IVM pode ser indicativa da presença de ácaros resistentes a esse ingrediente ativo. Universidad Nacional del Litoral 2020-06-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artículo original Original article application/pdf https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/9292 10.14409/favecv.v19i1.9292 FAVE Sección Ciencias Veterinarias; Vol. 19 Núm. 1 (2020): FAVE Sección Ciencias Veterinarias; 23-29 FAVE Sección Ciencias Veterinarias; Vol. 19 No. 1 (2020): FAVE Sección Ciencias Veterinarias; 23-29 FAVE Sección Ciencias Veterinarias; v. 19 n. 1 (2020): FAVE Sección Ciencias Veterinarias; 23-29 2362-5589 1666-938X 10.14409/favecv.v19i1 spa https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/9292/12692 Derechos de autor 2020 Marcela LARROZA, Paula SOLER, Carlos ROBLES, Raúl CABRERA, Candela CANTON, Carlos LANUSSE, Adrian Luis LIFSCHITZ

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