EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA

Implementation of intranasal administration for the delivery of drugs with site of action into the central nervous system, such as butorphanol, became a potential choice in equine medicine.  In this study, using Franz-diffusion cells the in vitro permeation rate through respiratory and olfa...

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Detalles Bibliográficos
Autor principal: Velloso, M I
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Litoral 2021
Materias:
butorphanol; formulation; intranasal administration; equines
butorfanol; formulación; administración intranasal; equinos
Acceso en línea:https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10945
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Biblioteca Virtual - Publicaciones (UNL) de Universidad Nacional del Litoral
id I26-R133-article-10945
record_format ojs
spelling I26-R133-article-109452021-12-06T16:24:00Z EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA EFECTO DE UN SURFACTANTE NO IONICO EN LA PERMEABILIDAD DE BUTORFANOL A TRAVES DE MUCOSA NASAL EQUINA Velloso, M I butorphanol; formulation; intranasal administration; equines butorfanol; formulación; administración intranasal; equinos Implementation of intranasal administration for the delivery of drugs with site of action into the central nervous system, such as butorphanol, became a potential choice in equine medicine.  In this study, using Franz-diffusion cells the in vitro permeation rate through respiratory and olfactory equine nasal mucosa of two butorphanol formulations was estimated and compared.  Both formulations had the same composition, was the exception for formulation 2, that contained 2, 5 x 10 -4 M of a non-ionic surfactant (tween 80). Butorphanol administered dose was 24, 4 mg/cm2. Plots of the cumulative amounts of butorphanol against time were constructed, where maximum flux values at the steady state (Jss), apparent permeability coefficients (Kp) and lag-time (tlag) were estimated. The Jss and Kp show that permeation of butorphanol through olfactory mucosa is different than respiratory mucosa. Moreover, Jss for formulation 2 was higher than formulation 1 in both anatomical areas, probably for the effect of the surfactant. The present results are promising to carry on with the development of formulation of butorphanol for intranasal administration. Universidad Nacional del Litoral 2021-12-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10945 10.14409/favecv.v19isuplemento.10945 FAVE Sección Ciencias Veterinarias; Vol. 19 Núm. suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; Vol. 19 No. suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; v. 19 n. suplemento (2021): FAVE Sección Ciencias Veterinarias 2362-5589 1666-938X 10.14409/favecv.v19isuplemento spa https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10945/14964 Derechos de autor 2021 M I Velloso
institution Universidad Nacional del Litoral
institution_str I-26
repository_str R-133
container_title_str Biblioteca Virtual - Publicaciones (UNL)
language Español
format Artículo revista
topic butorphanol; formulation; intranasal administration; equines
butorfanol; formulación; administración intranasal; equinos
spellingShingle butorphanol; formulation; intranasal administration; equines
butorfanol; formulación; administración intranasal; equinos
Velloso, M I
EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA
topic_facet butorphanol; formulation; intranasal administration; equines
butorfanol; formulación; administración intranasal; equinos
author Velloso, M I
author_facet Velloso, M I
author_sort Velloso, M I
title EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA
title_short EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA
title_full EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA
title_fullStr EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA
title_full_unstemmed EFFECT OF A NON-IONIC SURFACTANT ON THE PERMEABILITY OF BUTORPHANOL THROUGH EQUINE NASAL MUCOSA
title_sort effect of a non-ionic surfactant on the permeability of butorphanol through equine nasal mucosa
description Implementation of intranasal administration for the delivery of drugs with site of action into the central nervous system, such as butorphanol, became a potential choice in equine medicine.  In this study, using Franz-diffusion cells the in vitro permeation rate through respiratory and olfactory equine nasal mucosa of two butorphanol formulations was estimated and compared.  Both formulations had the same composition, was the exception for formulation 2, that contained 2, 5 x 10 -4 M of a non-ionic surfactant (tween 80). Butorphanol administered dose was 24, 4 mg/cm2. Plots of the cumulative amounts of butorphanol against time were constructed, where maximum flux values at the steady state (Jss), apparent permeability coefficients (Kp) and lag-time (tlag) were estimated. The Jss and Kp show that permeation of butorphanol through olfactory mucosa is different than respiratory mucosa. Moreover, Jss for formulation 2 was higher than formulation 1 in both anatomical areas, probably for the effect of the surfactant. The present results are promising to carry on with the development of formulation of butorphanol for intranasal administration.
publisher Universidad Nacional del Litoral
publishDate 2021
url https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10945
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AT vellosomi efectodeunsurfactantenoionicoenlapermeabilidaddebutorfanolatravesdemucosanasalequina
first_indexed 2023-07-05T23:06:09Z
last_indexed 2023-07-05T23:06:09Z
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