Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth
The successful use of transcriptional targeting for cancer therapy depends on the activity of a given promoter inside the malignant cell. Because solid human tumors evolve as a "cross-talk" between the different cell types within the tumor, we hypothesized that targeting the entire tumor m...
Guardado en:
| Autores principales: | Lopez, María V., Blanco, Patricia, Viale, Diego L., Cafferata, Eduardo G., Carbone, Cecilia, Gould, David, Chernajovsky, Yuti, Podhajcer, Osvaldo L. |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2006
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/83060 |
| Aporte de: |
Ejemplares similares
-
Proteomic analysis identified N-cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteines) activity in melanoma cells
por: Sosa, M.S., et al. -
Proteomic analysis identified N-cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteines) activity in melanoma cells
por: Sosa, María, et al.
Publicado: (2007) -
SPARC endogenous level, rather than fibroblast-produced SPARC or stroma reorganization induced by SPARC, is responsible for melanoma cell growth
por: Prada, Federico, et al.
Publicado: (2007) -
Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells
por: Fernanda Ledda, M., et al. -
Análisis proteómico de los mecanismos moleculares de progresión tumoral relacionados con la proteína Sparc
por: Girotti, María Romina
Publicado: (2010)