Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability

The thermodynamic functions Gibbs energy, enthalpy and entropy for the dissolution and mixing processes of triclosan (TS) in water are presented. These quantities were calculated by means of the van't Hoff and Gibbs equations from solubility values determined at temperatures ranging between 293...

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Detalles Bibliográficos
Autores principales: Delgado, Daniel R., Sosnik, Alejandro, Martínez, Fleming
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Agentes Antibacterianos
solubility; solution thermodynamics; transfer; triclosan
Procesos Químicos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8163
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8163
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Agentes Antibacterianos
solubility; solution thermodynamics; transfer; triclosan
Procesos Químicos
spellingShingle Farmacia
Agentes Antibacterianos
solubility; solution thermodynamics; transfer; triclosan
Procesos Químicos
Delgado, Daniel R.
Sosnik, Alejandro
Martínez, Fleming
Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
topic_facet Farmacia
Agentes Antibacterianos
solubility; solution thermodynamics; transfer; triclosan
Procesos Químicos
description The thermodynamic functions Gibbs energy, enthalpy and entropy for the dissolution and mixing processes of triclosan (TS) in water are presented. These quantities were calculated by means of the van't Hoff and Gibbs equations from solubility values determined at temperatures ranging between 293.15 and 313.15 K. In addition, the corresponding thermodynamic quantities of the drug transfer processes from water to different organic solvents displaying different hydrogen bonding capability were also calculated. In all the evaluated cases, Gibbs energy of transfer comprised negative values, indicating the preference of TS for all the organic media evaluated. Nevertheless, enthalpy and entropy of transfer assumed positive or negative values according to every specific system. It was clear that hydrogen bonding plays a significant role in the dissolution and transfer processes of this antibacterial agent.
format Articulo
Articulo
author Delgado, Daniel R.
Sosnik, Alejandro
Martínez, Fleming
author_facet Delgado, Daniel R.
Sosnik, Alejandro
Martínez, Fleming
author_sort Delgado, Daniel R.
title Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
title_short Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
title_full Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
title_fullStr Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
title_full_unstemmed Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
title_sort transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8163
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_7.pdf
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AT sosnikalejandro transferthermodynamicsoftriclosanfromwatertoorganicsolventswithdifferenthydrogenbondingcapability
AT martinezfleming transferthermodynamicsoftriclosanfromwatertoorganicsolventswithdifferenthydrogenbondingcapability
bdutipo_str Repositorios
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