Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Sep...

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Detalles Bibliográficos
Autores principales:	Dogan, Aysegul, Pehlivan, Ismail, Basci, Nursabah E.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Ergolinas cabergoline; capillary zone electrophoresis; pharmaceutical preparations; tablet; validation Electroforesis Capilar
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8112 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_20.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8112
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Ergolinas cabergoline; capillary zone electrophoresis; pharmaceutical preparations; tablet; validation Electroforesis Capilar
spellingShingle	Farmacia Ergolinas cabergoline; capillary zone electrophoresis; pharmaceutical preparations; tablet; validation Electroforesis Capilar Dogan, Aysegul Pehlivan, Ismail Basci, Nursabah E. Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
topic_facet	Farmacia Ergolinas cabergoline; capillary zone electrophoresis; pharmaceutical preparations; tablet; validation Electroforesis Capilar
description	A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.
format	Articulo Articulo
author	Dogan, Aysegul Pehlivan, Ismail Basci, Nursabah E.
author_facet	Dogan, Aysegul Pehlivan, Ismail Basci, Nursabah E.
author_sort	Dogan, Aysegul
title	Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
title_short	Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
title_full	Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
title_fullStr	Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
title_full_unstemmed	Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
title_sort	method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8112 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_20.pdf
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bdutipo_str	Repositorios
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Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

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