Formulation and pharmacodynamic evaluation of meloxicam liquisolid compacts
The purpose of this study was to improve the meloxicam dissolution rate through its formulation into liquisolid compacts and then to evaluate the in vitro and in vivo performance of the prepared liquisolid compacts. Dissolution efficiency, mean dissolution time and relative dissolution rate of liq...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8067 http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_6.pdf |
| Aporte de: |
| Sumario: | The purpose of this study was to improve the meloxicam dissolution rate through its formulation into
liquisolid compacts and then to evaluate the in vitro and in vivo performance of the prepared liquisolid compacts.
Dissolution efficiency, mean dissolution time and relative dissolution rate of liquisolid compacts were calculated
and compared to marketed formulation. The degree of interaction between the ME and excipients was
studied by differential scanning calorimetry and X-ray diffraction were used and results revealed that, there was
a loss of meloxicam crystallanity upon liquisolid formulation and almost molecularly dispersed state, which contributed
to the enhanced drug dissolution properties. The optimized liquisolid compact showed higher dissolution
rates and dissolution efficiency compared to commercial product. The analgesic and anti inflammatory response
of optimized liquisolid compact in Swiss albino mice and Wistar rats was found to be superior compared to the
marketed formulation. |
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