Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
The present study was designed to explore the ameliorative effect of hydroalcoholic extract of Emblica officinalis (HAE) on renal ischemia reperfusion (I/R) injury induced acute renal failure (ARF). Rats were subjected to administration of HAE (250 and 500 mg/kg, p.o. for 10 days) before one hour...
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| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8050 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_23.pdf |
| Aporte de: |
| Sumario: | The present study was designed to explore the ameliorative effect of hydroalcoholic extract of
Emblica officinalis (HAE) on renal ischemia reperfusion (I/R) injury induced acute renal failure (ARF).
Rats were subjected to administration of HAE (250 and 500 mg/kg, p.o. for 10 days) before one hour of the
ischemia (30 min) reperfusion (24 h) process on the 10th day of experiment. For evaluating the effect of
HAE on acute renal failure, Blood urea nitrogen (BUN) and creatinine (Cr) were estimated in serum sample
whereas, N-acetyl β-d-glucosaminidase (NAG) was estimated in urine sample. Further, renal tissue was
used to evaluate the oxidative stress markers and histopathological changes. The results demonstrated that
I/R caused marked changes in various biomarker levels. However, treatment with HAE significantly attenuated
these changes. Histopathological evaluation also revealed protective role of HAE on renal cortex and
tubular cells. These effects clearly indicated that HAE produced renoprotective effect against I/R induced
acute renal failure |
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