Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs
An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction...
Guardado en:
| Autores principales: | Asuaje, Agustín, Martín, Pedro, Enrique, Nicolás Jorge, Diaz Zegarra, Leandro Agustín, Smaldini, Paola Lorena, Docena, Guillermo Horacio, Milesi, Verónica |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107777 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5972794&blobtype=pdf https://www.tandfonline.com/doi/full/10.1080/19336950.2017.1331799 |
| Aporte de: |
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