Study of erythrocyte aggregation alterations in patients with ischemic stroke.
Isquemic stroke is the result of the evolution of atherothrombotic processes that are related to endothelial damage and dysfunction cause by chronic diseases such as hypertension and dyslipemia. Previous works has been...
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional de Rosario
2021
|
| Materias: | |
| Acceso en línea: | https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/30 |
| Aporte de: |
| id |
I15-R235-article-30 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-235 |
| container_title_str |
FCM Científica |
| language |
Español |
| format |
Artículo revista |
| topic |
Accidente cerebrovascular Agregación eritrocitaria Fibrinógeno Triglicéridos Isquemic stroke Erythrocyte aggregation Fibrinogen Triglycerides |
| spellingShingle |
Accidente cerebrovascular Agregación eritrocitaria Fibrinógeno Triglicéridos Isquemic stroke Erythrocyte aggregation Fibrinogen Triglycerides Capriotti Corrente, Jorge Svetaz, María J. Urli, Leda Raimondi, Elsa Luquita, Alejandra Study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| topic_facet |
Accidente cerebrovascular Agregación eritrocitaria Fibrinógeno Triglicéridos Isquemic stroke Erythrocyte aggregation Fibrinogen Triglycerides |
| author |
Capriotti Corrente, Jorge Svetaz, María J. Urli, Leda Raimondi, Elsa Luquita, Alejandra |
| author_facet |
Capriotti Corrente, Jorge Svetaz, María J. Urli, Leda Raimondi, Elsa Luquita, Alejandra |
| author_sort |
Capriotti Corrente, Jorge |
| title |
Study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| title_short |
Study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| title_full |
Study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| title_fullStr |
Study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| title_full_unstemmed |
Study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| title_sort |
study of erythrocyte aggregation alterations in patients with ischemic stroke. |
| description |
Isquemic stroke is the result of the evolution of atherothrombotic processes that are related to endothelial damage and dysfunction cause by chronic diseases such as hypertension and dyslipemia. Previous works has been reported about hemorheological disturbances in the course of cerebrovascular diseases, including increased erythrocyte aggregation (EA). The main objective of this study is to evaluate the changes in hemorrheological properties and in particular the erythrocyte aggregation process, which occur in 20 patients with ischemic stroke during the acute stage, compared to a control group (n=20) with similar risk factors. Concentration of fibrinogen (Fb), C reactive protein and triglycerides (TG) were determined in plasma. Into blood: EA, by optical densitometry, getting the average size of the aggregates and the initial speed of the process, erythrocyte sedimentation rate, erythrocyte rigidity index, blood viscosity, plasma viscosity and standardized relative blood viscosity at 45% hematocrit. We found that the erythrocytes of patients with stroke aggregate faster (0,92 ± 0,49 vs 0,64 ± 0,24, p <0,00001) and form larger aggregates (1,84 ± 0,07 vs 1,81 ± 0,07, p <0,05) than controls. This phenomenon correlated (r: Pearson’s coefficient) with plasma alterations, particularly with Fb (r = 0,565, p <0,01) and TG (r = 0,693, p <0,001). Identification of these factors is clinically relevant since it could have an impact on therapeutic strategies. |
| publisher |
Universidad Nacional de Rosario |
| publishDate |
2021 |
| url |
https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/30 |
| work_keys_str_mv |
AT capriotticorrentejorge studyoferythrocyteaggregationalterationsinpatientswithischemicstroke AT svetazmariaj studyoferythrocyteaggregationalterationsinpatientswithischemicstroke AT urlileda studyoferythrocyteaggregationalterationsinpatientswithischemicstroke AT raimondielsa studyoferythrocyteaggregationalterationsinpatientswithischemicstroke AT luquitaalejandra studyoferythrocyteaggregationalterationsinpatientswithischemicstroke AT capriotticorrentejorge estudiodelasalteracionesdelaagregacioneritrocitariaenpacientesconaccidentecerebrovascularisquemico AT svetazmariaj estudiodelasalteracionesdelaagregacioneritrocitariaenpacientesconaccidentecerebrovascularisquemico AT urlileda estudiodelasalteracionesdelaagregacioneritrocitariaenpacientesconaccidentecerebrovascularisquemico AT raimondielsa estudiodelasalteracionesdelaagregacioneritrocitariaenpacientesconaccidentecerebrovascularisquemico AT luquitaalejandra estudiodelasalteracionesdelaagregacioneritrocitariaenpacientesconaccidentecerebrovascularisquemico |
| first_indexed |
2023-06-26T22:50:57Z |
| last_indexed |
2024-08-12T21:45:31Z |
| _version_ |
1807219825560256512 |
| spelling |
I15-R235-article-302023-11-08T14:27:33Z Study of erythrocyte aggregation alterations in patients with ischemic stroke. Estudio de las alteraciones de la agregación eritrocitaria en pacientes con accidente cerebrovascular isquémico. Capriotti Corrente, Jorge Svetaz, María J. Urli, Leda Raimondi, Elsa Luquita, Alejandra Accidente cerebrovascular Agregación eritrocitaria Fibrinógeno Triglicéridos Isquemic stroke Erythrocyte aggregation Fibrinogen Triglycerides Isquemic stroke is the result of the evolution of atherothrombotic processes that are related to endothelial damage and dysfunction cause by chronic diseases such as hypertension and dyslipemia. Previous works has been reported about hemorheological disturbances in the course of cerebrovascular diseases, including increased erythrocyte aggregation (EA). The main objective of this study is to evaluate the changes in hemorrheological properties and in particular the erythrocyte aggregation process, which occur in 20 patients with ischemic stroke during the acute stage, compared to a control group (n=20) with similar risk factors. Concentration of fibrinogen (Fb), C reactive protein and triglycerides (TG) were determined in plasma. Into blood: EA, by optical densitometry, getting the average size of the aggregates and the initial speed of the process, erythrocyte sedimentation rate, erythrocyte rigidity index, blood viscosity, plasma viscosity and standardized relative blood viscosity at 45% hematocrit. We found that the erythrocytes of patients with stroke aggregate faster (0,92 ± 0,49 vs 0,64 ± 0,24, p <0,00001) and form larger aggregates (1,84 ± 0,07 vs 1,81 ± 0,07, p <0,05) than controls. This phenomenon correlated (r: Pearson’s coefficient) with plasma alterations, particularly with Fb (r = 0,565, p <0,01) and TG (r = 0,693, p <0,001). Identification of these factors is clinically relevant since it could have an impact on therapeutic strategies. El accidente cerebrovascular (ACV) isquémico es causado por evolución de procesos aterotrombóticos que se relacionan con daño y disfunción endotelial debido a patologías crónicas como hipertensión arterial y dislipemia. En trabajos previos se ha informado sobre alteraciones hemorreológicas en el curso de la patología vascular cerebral, en particular el incremento en la agregación eritrocitaria (AE). El presente trabajo tiene como objetivo principal estudiar las modificaciones de las propiedades hemorreológicas y en particular de la AE, en 20 pacientes con ACV isquémico durante la etapa aguda, en comparación a un grupo control (n = 20) con similares factores de riesgo. Se determinó en plasma: concentración de fibrinógeno, proteína C reactiva y triglicéridos. En sangre: agregación eritrocitaria por densitometría óptica, obteniéndose el tamaño promedio de los agregados y la velocidad inicial del proceso, velocidad de eritrosedimentación, índice de rigidez eritrocitaria, viscosidad sanguínea, viscosidad plasmática y viscosidad sanguínea relativa estandarizada a un hematocrito del 45%. Se encontró que los eritrocitos de los pacientes con ACV agregaron a mayor velocidad (0,92 ± 0,64 vs 0,49 ± 0,24; p < 0,00001) y formaron agregados de mayor tamaño (1,84 ± 0,07 vs 1,81 ± 0,07; p<0,05) que los controles. Este fenómeno correlacionó (r: coeficiente de Pearson) con las alteraciones encontradas en el plasma, en particular con las concentraciones séricas de fibrinógeno (r = 0,565; p <0,01) y triglicéridos (r = 0,693; p <0,001). La identificación de estos factores es de relevancia clínica ya que podría tener incidencia en las estrategias terapéuticas. Universidad Nacional de Rosario 2021-06-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/30 10.35305/fcm.v1i.30 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 1 (2020); 140-148 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/30/46 https://creativecommons.org/licenses/by-nc/4.0/ |