Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
In this paper the chemical imaging technique by near infrared spectroscopy was applied for characterization of drug formulations in tablets of sildenafil citrate of different sources. This work is original and has never been published because it was used the sildenafil citrate, including in the comm...
| Autores principales: | , , , , , |
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| Lenguaje: | Inglés |
| Publicado: |
Journal of Pharmaceutical and Biomedical Analysis
2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/9461 http://hdl.handle.net/2133/9461 |
| Aporte de: |
| id |
I15-R121-2133-9461 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Sildenafil citrate Chemical imaging Near infrared spectroscopy Multivariate curve resolution Classification Recognize the patterns |
| spellingShingle |
Sildenafil citrate Chemical imaging Near infrared spectroscopy Multivariate curve resolution Classification Recognize the patterns Poppi, Ronei Jesus Sabin, Guilherme Post Lozano, Valeria Antonella Fortunato de Carvalho Rocha, Werickson Ortiz, Rafael Romão, Wanderson Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| topic_facet |
Sildenafil citrate Chemical imaging Near infrared spectroscopy Multivariate curve resolution Classification Recognize the patterns |
| description |
In this paper the chemical imaging technique by near infrared spectroscopy was applied for characterization of drug formulations in tablets of sildenafil citrate of different sources. This work is original and has never been published because it was used the sildenafil citrate, including in the commercial one called "Viagra". In the first stage of the study, a chemometric method based on multivariate curve resolution was properly chosen for the development of the distribution map of concentrations of the active ingredient in tablets. In the second step, the normalized histograms of images from active ingredient were classified by hierarchical cluster analysis. Finally it was possible to recognize the patterns of homogeneity of images in sildenafil citrate tablet. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs. |
| author |
Poppi, Ronei Jesus Sabin, Guilherme Post Lozano, Valeria Antonella Fortunato de Carvalho Rocha, Werickson Ortiz, Rafael Romão, Wanderson |
| author_facet |
Poppi, Ronei Jesus Sabin, Guilherme Post Lozano, Valeria Antonella Fortunato de Carvalho Rocha, Werickson Ortiz, Rafael Romão, Wanderson |
| author_sort |
Poppi, Ronei Jesus |
| title |
Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| title_short |
Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| title_full |
Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| title_fullStr |
Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| title_full_unstemmed |
Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| title_sort |
characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools |
| publisher |
Journal of Pharmaceutical and Biomedical Analysis |
| publishDate |
2017 |
| url |
http://hdl.handle.net/2133/9461 http://hdl.handle.net/2133/9461 |
| work_keys_str_mv |
AT poppironeijesus characterizationofsildenafilcitratetabletsofdifferentsourcesbynearinfraredchemicalimagingandchemometrictools AT sabinguilhermepost characterizationofsildenafilcitratetabletsofdifferentsourcesbynearinfraredchemicalimagingandchemometrictools AT lozanovaleriaantonella characterizationofsildenafilcitratetabletsofdifferentsourcesbynearinfraredchemicalimagingandchemometrictools AT fortunatodecarvalhorochawerickson characterizationofsildenafilcitratetabletsofdifferentsourcesbynearinfraredchemicalimagingandchemometrictools AT ortizrafael characterizationofsildenafilcitratetabletsofdifferentsourcesbynearinfraredchemicalimagingandchemometrictools AT romaowanderson characterizationofsildenafilcitratetabletsofdifferentsourcesbynearinfraredchemicalimagingandchemometrictools |
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Repositorios |
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