Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable...
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Autores principales: | , , , , , , , , |
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Formato: | article artículo publishedVersion |
Lenguaje: | Inglés |
Publicado: |
MDPI Open Access Publishing
2013
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Materias: | |
Acceso en línea: | http://hdl.handle.net/2133/2584 http://hdl.handle.net/2133/2584 |
Aporte de: |
id |
I15-R121-2133-2584 |
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record_format |
dspace |
institution |
Universidad Nacional de Rosario |
institution_str |
I-15 |
repository_str |
R-121 |
collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
language |
Inglés |
orig_language_str_mv |
en |
topic |
benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study |
spellingShingle |
benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study Derita, Marcos del Olmo, Esther Barboza, Bianca García-Cadenas, Ana E. López-Pérez, José L. Andújar, Sebastián Enriz, Daniel Zacchino, Susana San Feliciano, Arturo Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents |
topic_facet |
benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study |
description |
Twenty-five polysubstituted phthalazinone derivatives were synthesized and
tested for their antifungal activity against a panel of pathogenic and clinically important
yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-
methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against
standardised strains of dermatophytes and Cryptococcus neoformans, as well as against
some clinical isolates. A physicochemical study performed on compound 5 revealed its
conformational and electronic characteristics, providing us with useful data for the future
design of novel related antifungal analogues. |
format |
article artículo publishedVersion |
author |
Derita, Marcos del Olmo, Esther Barboza, Bianca García-Cadenas, Ana E. López-Pérez, José L. Andújar, Sebastián Enriz, Daniel Zacchino, Susana San Feliciano, Arturo |
author_facet |
Derita, Marcos del Olmo, Esther Barboza, Bianca García-Cadenas, Ana E. López-Pérez, José L. Andújar, Sebastián Enriz, Daniel Zacchino, Susana San Feliciano, Arturo |
author_sort |
Derita, Marcos |
title |
Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents |
title_short |
Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents |
title_full |
Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents |
title_fullStr |
Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents |
title_full_unstemmed |
Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents |
title_sort |
synthesis, bioevaluation and structural study of substituted phthalazin-1(2h)-ones acting as antifungal agents |
publisher |
MDPI Open Access Publishing |
publishDate |
2013 |
url |
http://hdl.handle.net/2133/2584 http://hdl.handle.net/2133/2584 |
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