Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 and EW31/2022. Sequencin...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/25429 http://hdl.handle.net/2133/25429 |
| Aporte de: |
| id |
I15-R121-2133-25429 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| topic |
SARS-CoV-2 Omicron South America BA.1 BA.2 BA.4 BA.5 |
| spellingShingle |
SARS-CoV-2 Omicron South America BA.1 BA.2 BA.4 BA.5 Torres, Carolina Nabaes Jodar, Mercedes Acuña, Dolores Zambrana Montaño, Romina Micaela Culasso, Andrés Carlos Alberto Amadio, Ariel Fernando Aulicino, Paula Ceballos, Santiago Cacciabue, Marco Debat, Humberto Dus Santos, María José Eberhardt, María Florencia Espul, Carlos Fay, Fabián Fernández, María Ailén Fernández, Franco Fernandez Muñoz, Juan Manuel Ferrini, Florencia Gallego, Fernando Giri, Adriana Angélica Cerri, Agustina Bolatti, Elisa María Gismondi, María Ines Goya, Stephanie Gramundi, Iván Irazoqui, José Matías König, Guido Alberto Leiva, Viviana Lucero, Horacio Marquez, Nathalie Nardi, Cristina Ortiz, Belén Pianciola, Luis Pintos, Carolina Beatriz Puebla, Andrea Fabiana Rastellini, Carolina Victoria Rojas, Alejandro Ezequiel Sfalcin, Javier Suárez, Ariel Tittarelli, Estefanía Toro, Rosana Villanova, Gabriela Vanina Ziehm, María Cecilia Zimmermann, María Carla Zunino, Sebastián Proyecto PAIS Working Group Valinotto, Laura Viegas, Mariana Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 |
| topic_facet |
SARS-CoV-2 Omicron South America BA.1 BA.2 BA.4 BA.5 |
| description |
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study
the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19
in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between
EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed.
A differential dynamic between the Omicron waves was found. The third wave was associated with
lineage BA.1, characterized by a high number of cases, very fast displacement of Delta, doubling times
of 3.3 days and a low level of lineage diversity and clustering. In contrast, the fourth wave was longer
but associated with a lower number of cases, initially caused by BA.2, and later by BA.4/BA.5, with
doubling times of about 10 days. Several BA.2 and BA.4/BA.5 sublineages and introductions were
detected, although very few clusters with a constrained geographical distribution were observed,
suggesting limited transmission chains. The differential dynamic could be due to waning immunity
and an increase in population gatherings in the BA.1 wave, and a boosted population (for vaccination
or recent prior immunity for BA.1 infection) in the wave caused by BA2/BA.4/BA.5, which may have
limited the establishment of the new lineages. |
| format |
article artículo publishedVersion |
| author |
Torres, Carolina Nabaes Jodar, Mercedes Acuña, Dolores Zambrana Montaño, Romina Micaela Culasso, Andrés Carlos Alberto Amadio, Ariel Fernando Aulicino, Paula Ceballos, Santiago Cacciabue, Marco Debat, Humberto Dus Santos, María José Eberhardt, María Florencia Espul, Carlos Fay, Fabián Fernández, María Ailén Fernández, Franco Fernandez Muñoz, Juan Manuel Ferrini, Florencia Gallego, Fernando Giri, Adriana Angélica Cerri, Agustina Bolatti, Elisa María Gismondi, María Ines Goya, Stephanie Gramundi, Iván Irazoqui, José Matías König, Guido Alberto Leiva, Viviana Lucero, Horacio Marquez, Nathalie Nardi, Cristina Ortiz, Belén Pianciola, Luis Pintos, Carolina Beatriz Puebla, Andrea Fabiana Rastellini, Carolina Victoria Rojas, Alejandro Ezequiel Sfalcin, Javier Suárez, Ariel Tittarelli, Estefanía Toro, Rosana Villanova, Gabriela Vanina Ziehm, María Cecilia Zimmermann, María Carla Zunino, Sebastián Proyecto PAIS Working Group Valinotto, Laura Viegas, Mariana |
| author_facet |
Torres, Carolina Nabaes Jodar, Mercedes Acuña, Dolores Zambrana Montaño, Romina Micaela Culasso, Andrés Carlos Alberto Amadio, Ariel Fernando Aulicino, Paula Ceballos, Santiago Cacciabue, Marco Debat, Humberto Dus Santos, María José Eberhardt, María Florencia Espul, Carlos Fay, Fabián Fernández, María Ailén Fernández, Franco Fernandez Muñoz, Juan Manuel Ferrini, Florencia Gallego, Fernando Giri, Adriana Angélica Cerri, Agustina Bolatti, Elisa María Gismondi, María Ines Goya, Stephanie Gramundi, Iván Irazoqui, José Matías König, Guido Alberto Leiva, Viviana Lucero, Horacio Marquez, Nathalie Nardi, Cristina Ortiz, Belén Pianciola, Luis Pintos, Carolina Beatriz Puebla, Andrea Fabiana Rastellini, Carolina Victoria Rojas, Alejandro Ezequiel Sfalcin, Javier Suárez, Ariel Tittarelli, Estefanía Toro, Rosana Villanova, Gabriela Vanina Ziehm, María Cecilia Zimmermann, María Carla Zunino, Sebastián Proyecto PAIS Working Group Valinotto, Laura Viegas, Mariana |
| author_sort |
Torres, Carolina |
| title |
Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 |
| title_short |
Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 |
| title_full |
Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 |
| title_fullStr |
Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 |
| title_full_unstemmed |
Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 |
| title_sort |
omicron waves in argentina: dynamics of sars-cov-2 lineages ba.1, ba.2 and the emerging ba.2.12.1 and ba.4/ba.5 |
| publisher |
MDPI |
| publishDate |
2023 |
| url |
http://hdl.handle.net/2133/25429 http://hdl.handle.net/2133/25429 |
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