Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression

Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of relevant cellular targets. Among them, the expression of some PDZ-containing polarity...

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Detalles Bibliográficos
Autores principales: Dizanzo, María Paula, Bugnon Valdano, Marina Paula, Basukala, Om, Banks, Lawrence, Gardiol, Daniela
Lenguaje:Inglés
Publicado: BMC 2022
Materias:
HPV E7
CKII
PDZ
DLG1 hScrib
Acceso en línea:http://hdl.handle.net/2133/25026
http://hdl.handle.net/2133/25026
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-25026
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
topic HPV E7
CKII
PDZ
DLG1 hScrib
spellingShingle HPV E7
CKII
PDZ
DLG1 hScrib
Dizanzo, María Paula
Bugnon Valdano, Marina Paula
Basukala, Om
Banks, Lawrence
Gardiol, Daniela
Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
topic_facet HPV E7
CKII
PDZ
DLG1 hScrib
description Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of relevant cellular targets. Among them, the expression of some PDZ-containing polarity proteins, as DLG1 and hScrib, is altered during the HPV life cycle and the consequent malignant transformation. Together with the well-established interference of E6 with PDZ proteins, we have recently shown that E7 viral oncoprotein is also responsible for the changes in abundance and localization of DLG1 observed in HPV-associated lesions. Given that the mechanisms involved remained only partially understood, we here thoroughly analyse the contribution of a crucial E7 post-translational modifcation: its CKII-dependent phosphorylation. Moreover, we extended our studies to hScrib, in order to investigate possible conserved regulatory events among diverse PDZ targets of HPV.
author Dizanzo, María Paula
Bugnon Valdano, Marina Paula
Basukala, Om
Banks, Lawrence
Gardiol, Daniela
author_facet Dizanzo, María Paula
Bugnon Valdano, Marina Paula
Basukala, Om
Banks, Lawrence
Gardiol, Daniela
author_sort Dizanzo, María Paula
title Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
title_short Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
title_full Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
title_fullStr Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
title_full_unstemmed Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
title_sort novel effect of the high risk-hpv e7 ckii phospho-acceptor site on polarity protein expression
publisher BMC
publishDate 2022
url http://hdl.handle.net/2133/25026
http://hdl.handle.net/2133/25026
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