The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due to the production of bacterial enzymes called β-lactamases, has been partially solved by the introduction of...

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Autores principales:	Mojica, Maria F., Rossi, María Agustina, Vila, Alejandro J., Bonomo, Robert A.
Formato:	article artículo
Lenguaje:	Inglés
Publicado:	Elsevier Ltd 2022
Materias:	Anti-bacterial agents Beta-lactamase inhibitors Drug resistance Beta-lactams Coinfection Bacterial Global health
Acceso en línea:	http://hdl.handle.net/2133/23377 http://hdl.handle.net/2133/23377
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-23377
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institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Anti-bacterial agents Beta-lactamase inhibitors Drug resistance Beta-lactams Coinfection Bacterial Global health
spellingShingle	Anti-bacterial agents Beta-lactamase inhibitors Drug resistance Beta-lactams Coinfection Bacterial Global health Mojica, Maria F. Rossi, María Agustina Vila, Alejandro J. Bonomo, Robert A. The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
topic_facet	Anti-bacterial agents Beta-lactamase inhibitors Drug resistance Beta-lactams Coinfection Bacterial Global health
description	Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due to the production of bacterial enzymes called β-lactamases, has been partially solved by the introduction of β-lactamase inhibitors, which restore the activity of otherwise obsolete molecules. This solution is limited because currently available β-lactamase inhibitors only work against serine β-lactamases, whereas metallo-β-lactamases continue to spread, evolve, and confer resistance to all β-lactams, including carbapenems. Furthermore, the increased use of antibiotics to treat secondary bacterial pneumonia in severely sick patients with COVID-19 might exacerbate the problem of antimicrobial resistance. In this Personal View, we summarise the main advances accomplished in this area of research, emphasise the main challenges that need to be solved, and the importance of research on inhibitors for metallo-B-lactamases amidst the current pandemic.
format	article artículo
author	Mojica, Maria F. Rossi, María Agustina Vila, Alejandro J. Bonomo, Robert A.
author_facet	Mojica, Maria F. Rossi, María Agustina Vila, Alejandro J. Bonomo, Robert A.
author_sort	Mojica, Maria F.
title	The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
title_short	The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
title_full	The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
title_fullStr	The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
title_full_unstemmed	The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
title_sort	urgent need for metallo-β-lactamase inhibitors: an unattended global threat
publisher	Elsevier Ltd
publishDate	2022
url	http://hdl.handle.net/2133/23377 http://hdl.handle.net/2133/23377
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The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

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