Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes

Metamorphosis is a captivating process of change during which the morphology of the larva is completely reshaped to face the new challenges of adult life. In the case of fish, this process initiated in the brain has traditionally been considered to be a critical rearing point and despite the pioneer...

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Autores principales:	Guerrero Peña, Laura, Suarez Bregua, Paula, Méndez Martínez, Luis, García Fernández, Pablo, Tur, Ricardo, Rubiolo, Juan Andrés, Tena, Juan J., Rotllant, Josep
Formato:	article artículo
Lenguaje:	Inglés
Publicado:	MDPI 2022
Materias:	Turbot Metamorphosis Brain RNA Sequencing Transcriptome
Acceso en línea:	http://hdl.handle.net/2133/23342 http://hdl.handle.net/2133/23342
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-23342
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Turbot Metamorphosis Brain RNA Sequencing Transcriptome
spellingShingle	Turbot Metamorphosis Brain RNA Sequencing Transcriptome Guerrero Peña, Laura Suarez Bregua, Paula Méndez Martínez, Luis García Fernández, Pablo Tur, Ricardo Rubiolo, Juan Andrés Tena, Juan J. Rotllant, Josep Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
topic_facet	Turbot Metamorphosis Brain RNA Sequencing Transcriptome
description	Metamorphosis is a captivating process of change during which the morphology of the larva is completely reshaped to face the new challenges of adult life. In the case of fish, this process initiated in the brain has traditionally been considered to be a critical rearing point and despite the pioneering molecular work carried out in other flatfishes, the underlying molecular basis is still relatively poorly characterized. Turbot brain transcriptome of three developmental stages (pre-metamorphic, climax of metamorphosis and post-metamorphic) were analyzed to study the gene expression dynamics throughout the metamorphic process. A total of 1570 genes were differentially expressed in the three developmental stages and we found a specific pattern of gene expression at each stage. Unexpectedly, at the climax stage of metamorphosis, we found highly expressed genes related to the immune response, while the biological pathway enrichment analysis in pre-metamorphic and post-metamorphic were related to cell differentiation and oxygen carrier activity, respectively. In addition, our results confirm the importance of thyroid stimulating hormone, increasing its expression during metamorphosis. Based on our findings, we assume that immune system activation during the climax of metamorphosis stage could be related to processes of larval tissue inflammation, resorption and replacement, as occurs in other vertebrates.
format	article artículo
author	Guerrero Peña, Laura Suarez Bregua, Paula Méndez Martínez, Luis García Fernández, Pablo Tur, Ricardo Rubiolo, Juan Andrés Tena, Juan J. Rotllant, Josep
author_facet	Guerrero Peña, Laura Suarez Bregua, Paula Méndez Martínez, Luis García Fernández, Pablo Tur, Ricardo Rubiolo, Juan Andrés Tena, Juan J. Rotllant, Josep
author_sort	Guerrero Peña, Laura
title	Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
title_short	Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
title_full	Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
title_fullStr	Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
title_full_unstemmed	Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
title_sort	brains in metamorphosis: temporal transcriptome dynamics in hatchery-reared flatfishes
publisher	MDPI
publishDate	2022
url	http://hdl.handle.net/2133/23342 http://hdl.handle.net/2133/23342
work_keys_str_mv	AT guerreropenalaura brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT suarezbreguapaula brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT mendezmartinezluis brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT garciafernandezpablo brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT turricardo brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT rubiolojuanandres brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT tenajuanj brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes AT rotllantjosep brainsinmetamorphosistemporaltranscriptomedynamicsinhatcheryrearedflatfishes
bdutipo_str	Repositorios
_version_	1764820412011642881

Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes

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