Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models

Despite its effectiveness as an antineoplastic drug, doxorubicin (DOX) is usually associated with cardiotoxicity. Lovastatin (LOV), a hypolipidemic agent used in the clinic, has been demonstrated to have antitumoral and antimetastatic effects in murine models. Since the two agents arrest tumor cells...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rozados, Viviana R., Hinrichsen, Lucila Isabel, Binda, María Mercedes, Gervasoni, Silvia I., Matar, Pablo, Bonfil, Daniel R., Scharovsky, O. Graciela
Formato:	artículo publishedVersion article
Lenguaje:	Inglés
Publicado:	Spandidos (Grecia) 2012
Materias:	Lovastatin Doxorubicin Apoptosis
Acceso en línea:	http://hdl.handle.net/2133/2014 http://hdl.handle.net/2133/2014
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-2014
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	en
topic	Lovastatin Doxorubicin Apoptosis
spellingShingle	Lovastatin Doxorubicin Apoptosis Rozados, Viviana R. Hinrichsen, Lucila Isabel Binda, María Mercedes Gervasoni, Silvia I. Matar, Pablo Bonfil, Daniel R. Scharovsky, O. Graciela Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
topic_facet	Lovastatin Doxorubicin Apoptosis
description	Despite its effectiveness as an antineoplastic drug, doxorubicin (DOX) is usually associated with cardiotoxicity. Lovastatin (LOV), a hypolipidemic agent used in the clinic, has been demonstrated to have antitumoral and antimetastatic effects in murine models. Since the two agents arrest tumor cells in different phases of the cell cycle and induce apoptosis, the goal of this study was to examine the efficacy of a combination therapy with LOV and low doses of DOX, in an attempt to obtain an improved antitumoral effect devoid of toxicity, by using a rat B-cell lymphoma and a mouse mammary tumor. In the two models, the combined treatment showed a synergistic antitumoral effect, which is mainly ascribed to an increased apoptotic response elicited by a LOV/DOX combination than either agent alone. The therapeutic benefit demonstrated by the combination treatment is further emphasized by the lack of toxicity.
format	artículo publishedVersion article
author	Rozados, Viviana R. Hinrichsen, Lucila Isabel Binda, María Mercedes Gervasoni, Silvia I. Matar, Pablo Bonfil, Daniel R. Scharovsky, O. Graciela
author_facet	Rozados, Viviana R. Hinrichsen, Lucila Isabel Binda, María Mercedes Gervasoni, Silvia I. Matar, Pablo Bonfil, Daniel R. Scharovsky, O. Graciela
author_sort	Rozados, Viviana R.
title	Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
title_short	Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
title_full	Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
title_fullStr	Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
title_full_unstemmed	Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
title_sort	lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models
publisher	Spandidos (Grecia)
publishDate	2012
url	http://hdl.handle.net/2133/2014 http://hdl.handle.net/2133/2014
work_keys_str_mv	AT rozadosvivianar lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels AT hinrichsenlucilaisabel lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels AT bindamariamercedes lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels AT gervasonisilviai lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels AT matarpablo lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels AT bonfildanielr lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels AT scharovskyograciela lovastatinenhancestheantitumoralandapoptoticactivityofdoxorubicininmurinetumormodels
bdutipo_str	Repositorios
_version_	1764820411327971328

Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models

Ejemplares similares