Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity

BACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided in...

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Autores principales: Rozados, Viviana R., Sánchez, Andrea M., Gervasoni, Silvia I., Berra, Héctor H., Matar, Pablo, Scharovsky, O. Graciela
Formato: artículo publishedVersion article
Lenguaje:Inglés
Publicado: Oxford University Press 2012
Materias:
Cyclophosphamide
Lymphoma
Metronomic dosing
Sarcoma
Toxicity
Acceso en línea:http://hdl.handle.net/2133/2013
http://hdl.handle.net/2133/2013
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-2013
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv en
topic Cyclophosphamide
Lymphoma
Metronomic dosing
Sarcoma
Toxicity
spellingShingle Cyclophosphamide
Lymphoma
Metronomic dosing
Sarcoma
Toxicity
Rozados, Viviana R.
Sánchez, Andrea M.
Gervasoni, Silvia I.
Berra, Héctor H.
Matar, Pablo
Scharovsky, O. Graciela
Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
topic_facet Cyclophosphamide
Lymphoma
Metronomic dosing
Sarcoma
Toxicity
description BACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided into two groups: group I, control, injected with saline three times a week; and group II, treated with Cy 10 mg/kg three times a week, from day 10 until the tumour was non-palpable, or 5 mg/kg three times a week from day 7. Tumours were measured and animals were weighed twice weekly. Periodic blood samples were taken for determination of urea, creatinine, serum glutamic-oxaloacetic transaminase, lactate dehydrogenase and haematological parameters. RESULTS: The administration of low-dose Cy eradicated established rat lymphomas and sarcomas; there was neither metastatic growth nor recurrence at primary sites for 100% of the lymphomas and 83% of the sarcomas. In addition, the treatment did not cause weight loss, and was devoid of haematological, cardiac, hepatic and renal toxicity. CONCLUSIONS: Metronomic administration of Cy at low doses on a thrice weekly schedule to already grown rat lymphomas and sarcomas demonstrated itself to be a successful antitumour therapy that did not cause weight loss and was devoid of haematological, cardiac, hepatic and renal toxicity.
format artículo
publishedVersion
article
author Rozados, Viviana R.
Sánchez, Andrea M.
Gervasoni, Silvia I.
Berra, Héctor H.
Matar, Pablo
Scharovsky, O. Graciela
author_facet Rozados, Viviana R.
Sánchez, Andrea M.
Gervasoni, Silvia I.
Berra, Héctor H.
Matar, Pablo
Scharovsky, O. Graciela
author_sort Rozados, Viviana R.
title Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
title_short Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
title_full Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
title_fullStr Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
title_full_unstemmed Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
title_sort metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
publisher Oxford University Press
publishDate 2012
url http://hdl.handle.net/2133/2013
http://hdl.handle.net/2133/2013
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