The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen

Acinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbio...

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Autores principales: Repizo, Guillermo Daniel, Viale, Alejandro M., Borges, Vítor, Cameranesi, María Marcela, Taib, Najwa, Espariz, Martín, Brochier-Armanet, Céline, Gomes, João Paulo, Salcedo, Suzana P.
Formato: publishedVersion
Lenguaje:Inglés
Publicado: Oxford University Press 2021
Materias:
Comparative Genomics
Pre-antibiotic Era
Virulence Factors
CRISPR-cas
Acceso en línea:http://hdl.handle.net/2133/20126
http://hdl.handle.net/2133/20126
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-20126
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Comparative Genomics
Pre-antibiotic Era
Virulence Factors
CRISPR-cas
spellingShingle Comparative Genomics
Pre-antibiotic Era
Virulence Factors
CRISPR-cas
Repizo, Guillermo Daniel
Viale, Alejandro M.
Borges, Vítor
Cameranesi, María Marcela
Taib, Najwa
Espariz, Martín
Brochier-Armanet, Céline
Gomes, João Paulo
Salcedo, Suzana P.
The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
topic_facet Comparative Genomics
Pre-antibiotic Era
Virulence Factors
CRISPR-cas
description Acinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbiota responsible of the aerobic decomposition of the resinous desert shrub guayule. Whole-genome sequencing and phylogenetic analysis based on core genes confirmed DSM30011 affiliation to A. baumannii. Comparative studies with 32 complete A. baumannii genomes revealed the presence of 12 unique accessory chromosomal regions in DSM30011 including five encompassing phage-related genes, five containing toxin genes of the type-6 secretion system, and one with an atypical CRISPRs/cas cluster. No antimicrobial resistance islands were identified in DSM30011 agreeingwithageneralantimicrobialsusceptibilityphenotypeincludingfolatesynthesisinhibitors.Themarginalampicillinresistance of DSM30011 most likely derived from chromosomal ADC-type ampC and blaOXA-51-type genes. Searching for catabolic pathways genes revealed several clusters involved in the degradation of plant defenses including woody tissues and a previously unreported atu locus responsible of aliphatic terpenes degradation, thus suggesting that resinous plants may provide an effective niche for this organism. DSM30011 also harbored most genes and regulatory mechanisms linked to persistence and virulence in pathogenicAcinetobacterspecies. This strain thus revealed important clues into the genomic diversity, virulence potential, and niche ranges of the preantibiotic era A. baumannii population, and may provide an useful tool for our understanding of the processes that led to the recent evolution of this species toward an opportunistic pathogen of humans.
format publishedVersion
author Repizo, Guillermo Daniel
Viale, Alejandro M.
Borges, Vítor
Cameranesi, María Marcela
Taib, Najwa
Espariz, Martín
Brochier-Armanet, Céline
Gomes, João Paulo
Salcedo, Suzana P.
author_facet Repizo, Guillermo Daniel
Viale, Alejandro M.
Borges, Vítor
Cameranesi, María Marcela
Taib, Najwa
Espariz, Martín
Brochier-Armanet, Céline
Gomes, João Paulo
Salcedo, Suzana P.
author_sort Repizo, Guillermo Daniel
title The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
title_short The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
title_full The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
title_fullStr The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
title_full_unstemmed The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
title_sort environmental acinetobacter baumannii isolate dsm30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen
publisher Oxford University Press
publishDate 2021
url http://hdl.handle.net/2133/20126
http://hdl.handle.net/2133/20126
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