Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus
Several Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii as the species of greatest concern worldwide due to its multi-drug resistance and recent appearance of hyper-virulent strains in the clinical setting. Acinetobacter colonization of the environment and t...
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| Autores principales: | , , , |
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| Formato: | publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2021
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/20046 http://hdl.handle.net/2133/20046 |
| Aporte de: |
| id |
I15-R121-2133-20046 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Comparative Genomics Toxins PAAR Proteins VgrG Proteins Type VI Secretion Systems Acinetobacter |
| spellingShingle |
Comparative Genomics Toxins PAAR Proteins VgrG Proteins Type VI Secretion Systems Acinetobacter Repizo, Guillermo Daniel Espariz, Martín Seravalle, Joana L. Salcedo, Suzana P. Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus |
| topic_facet |
Comparative Genomics Toxins PAAR Proteins VgrG Proteins Type VI Secretion Systems Acinetobacter |
| description |
Several Acinetobacter strains are important nosocomial pathogens, with Acinetobacter
baumannii as the species of greatest concern worldwide due to its multi-drug resistance
and recent appearance of hyper-virulent strains in the clinical setting. Acinetobacter
colonization of the environment and the host is associated with a multitude of
factors which remain poorly characterized. Among them, the secretion systems (SS)
encoded by Acinetobacter species confer adaptive advantages depending on the
niche occupied. Different SS have been characterized in this group of microorganisms,
including T6SS used by several Acinetobacter species to outcompete other bacteria
and in some A. baumannii strains for Galleria mellonella colonization. Therefore, to
better understand the distribution of the T6SS in this genus we carried out an in depth comparative genomic analysis of the T6SS in 191 sequenced strains. To this
end, we analyzed the gene content, sequence similarity, synteny and operon structure
of each T6SS loci. The presence of a single conserved T6SS-main cluster (T6SS-1),
with two different genetic organizations, was detected in the genomes of several
ecologically diverse species. Furthermore, a second main cluster (T6SS-2) was detected
in a subgroup of 3 species of environmental origin. Detailed analysis also showed an
impressive genetic versatility in T6SS-associated islands, carrying VgrG, PAAR and
putative toxin-encoding genes. This in silico study represents the first detailed intra species comparative analysis of T6SS-associated genes in the Acinetobacter genus,
that should contribute to the future experimental characterization of T6SS proteins
and effectors. |
| format |
publishedVersion |
| author |
Repizo, Guillermo Daniel Espariz, Martín Seravalle, Joana L. Salcedo, Suzana P. |
| author_facet |
Repizo, Guillermo Daniel Espariz, Martín Seravalle, Joana L. Salcedo, Suzana P. |
| author_sort |
Repizo, Guillermo Daniel |
| title |
Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus |
| title_short |
Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus |
| title_full |
Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus |
| title_fullStr |
Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus |
| title_full_unstemmed |
Bioinformatic analysis of the Type VI Secretion System and its potential toxins in the Acinetobacter genus |
| title_sort |
bioinformatic analysis of the type vi secretion system and its potential toxins in the acinetobacter genus |
| publisher |
Frontiers Media |
| publishDate |
2021 |
| url |
http://hdl.handle.net/2133/20046 http://hdl.handle.net/2133/20046 |
| work_keys_str_mv |
AT repizoguillermodaniel bioinformaticanalysisofthetypevisecretionsystemanditspotentialtoxinsintheacinetobactergenus AT esparizmartin bioinformaticanalysisofthetypevisecretionsystemanditspotentialtoxinsintheacinetobactergenus AT seravallejoanal bioinformaticanalysisofthetypevisecretionsystemanditspotentialtoxinsintheacinetobactergenus AT salcedosuzanap bioinformaticanalysisofthetypevisecretionsystemanditspotentialtoxinsintheacinetobactergenus |
| bdutipo_str |
Repositorios |
| _version_ |
1764820411272396805 |