Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
Copper is an essential cofactor for aerobic respiration, since it is required as a redox cofactor in Cytochrome c Oxidase (COX). This ancient and highly conserved enzymatic complex from the family of heme-copper oxidase possesses two copper sites: CuA and CuB. Biosynthesis of the oxidase is a com...
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Autores principales: | , , |
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Formato: | article artículo publishedVersion |
Lenguaje: | Inglés |
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MDPI
2021
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Materias: | |
Acceso en línea: | http://hdl.handle.net/2133/20012 http://hdl.handle.net/2133/20012 |
Aporte de: |
id |
I15-R121-2133-20012 |
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record_format |
dspace |
institution |
Universidad Nacional de Rosario |
institution_str |
I-15 |
repository_str |
R-121 |
collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
language |
Inglés |
topic |
Copper Site Assembly Heme-Copper Oxidases Copper Trafficking Metallochaperones |
spellingShingle |
Copper Site Assembly Heme-Copper Oxidases Copper Trafficking Metallochaperones Llases, María Eugenia Morgada, Marcos Nicolás Vila, Alejandro J. Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
topic_facet |
Copper Site Assembly Heme-Copper Oxidases Copper Trafficking Metallochaperones |
description |
Copper is an essential cofactor for aerobic respiration, since it is required as a redox cofactor
in Cytochrome c Oxidase (COX). This ancient and highly conserved enzymatic complex from the
family of heme-copper oxidase possesses two copper sites: CuA and CuB. Biosynthesis of the oxidase
is a complex, stepwise process that requires a high number of assembly factors. In this review, we
summarize the state-of-the-art in the assembly of COX, with special emphasis in the assembly of
copper sites. Assembly of the CuA site is better understood, being at the same time highly variable
among organisms. We also discuss the current challenges that prevent the full comprehension of the
mechanisms of assembly and the pending issues in the field. |
format |
article artículo publishedVersion |
author |
Llases, María Eugenia Morgada, Marcos Nicolás Vila, Alejandro J. |
author_facet |
Llases, María Eugenia Morgada, Marcos Nicolás Vila, Alejandro J. |
author_sort |
Llases, María Eugenia |
title |
Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
title_short |
Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
title_full |
Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
title_fullStr |
Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
title_full_unstemmed |
Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
title_sort |
biochemistry of copper site assembly in heme-copper oxidases: a theme with variations |
publisher |
MDPI |
publishDate |
2021 |
url |
http://hdl.handle.net/2133/20012 http://hdl.handle.net/2133/20012 |
work_keys_str_mv |
AT llasesmariaeugenia biochemistryofcoppersiteassemblyinhemecopperoxidasesathemewithvariations AT morgadamarcosnicolas biochemistryofcoppersiteassemblyinhemecopperoxidasesathemewithvariations AT vilaalejandroj biochemistryofcoppersiteassemblyinhemecopperoxidasesathemewithvariations |
bdutipo_str |
Repositorios |
_version_ |
1764820411247230980 |