Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations

Copper is an essential cofactor for aerobic respiration, since it is required as a redox cofactor in Cytochrome c Oxidase (COX). This ancient and highly conserved enzymatic complex from the family of heme-copper oxidase possesses two copper sites: CuA and CuB. Biosynthesis of the oxidase is a com...

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Autores principales: Llases, María Eugenia, Morgada, Marcos Nicolás, Vila, Alejandro J.
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: MDPI 2021
Materias:
Copper Site Assembly
Heme-Copper Oxidases
Copper Trafficking
Metallochaperones
Acceso en línea:http://hdl.handle.net/2133/20012
http://hdl.handle.net/2133/20012
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-20012
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
topic Copper Site Assembly
Heme-Copper Oxidases
Copper Trafficking
Metallochaperones
spellingShingle Copper Site Assembly
Heme-Copper Oxidases
Copper Trafficking
Metallochaperones
Llases, María Eugenia
Morgada, Marcos Nicolás
Vila, Alejandro J.
Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
topic_facet Copper Site Assembly
Heme-Copper Oxidases
Copper Trafficking
Metallochaperones
description Copper is an essential cofactor for aerobic respiration, since it is required as a redox cofactor in Cytochrome c Oxidase (COX). This ancient and highly conserved enzymatic complex from the family of heme-copper oxidase possesses two copper sites: CuA and CuB. Biosynthesis of the oxidase is a complex, stepwise process that requires a high number of assembly factors. In this review, we summarize the state-of-the-art in the assembly of COX, with special emphasis in the assembly of copper sites. Assembly of the CuA site is better understood, being at the same time highly variable among organisms. We also discuss the current challenges that prevent the full comprehension of the mechanisms of assembly and the pending issues in the field.
format article
artículo
publishedVersion
author Llases, María Eugenia
Morgada, Marcos Nicolás
Vila, Alejandro J.
author_facet Llases, María Eugenia
Morgada, Marcos Nicolás
Vila, Alejandro J.
author_sort Llases, María Eugenia
title Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
title_short Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
title_full Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
title_fullStr Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
title_full_unstemmed Biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
title_sort biochemistry of copper site assembly in heme-copper oxidases: a theme with variations
publisher MDPI
publishDate 2021
url http://hdl.handle.net/2133/20012
http://hdl.handle.net/2133/20012
work_keys_str_mv AT llasesmariaeugenia biochemistryofcoppersiteassemblyinhemecopperoxidasesathemewithvariations
AT morgadamarcosnicolas biochemistryofcoppersiteassemblyinhemecopperoxidasesathemewithvariations
AT vilaalejandroj biochemistryofcoppersiteassemblyinhemecopperoxidasesathemewithvariations
bdutipo_str Repositorios
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