Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends

Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cau...

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Detalles Bibliográficos
Autores principales: Tamma, Grazia, Valenti, Giovanna, Grossini, Elena, Donnini, Sandra, Marino, Angela, Marinelli, Raúl A., Calamita, Giuseppe
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Hindawi 2021
Materias:
Aquaporin Membrane Channels
Oxidative Stress
Signaling
Aging
Acceso en línea:http://hdl.handle.net/2133/19959
http://hdl.handle.net/2133/19959
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19959
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Aquaporin Membrane Channels
Oxidative Stress
Signaling
Aging
spellingShingle Aquaporin Membrane Channels
Oxidative Stress
Signaling
Aging
Tamma, Grazia
Valenti, Giovanna
Grossini, Elena
Donnini, Sandra
Marino, Angela
Marinelli, Raúl A.
Calamita, Giuseppe
Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
topic_facet Aquaporin Membrane Channels
Oxidative Stress
Signaling
Aging
description Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.
format article
artículo
publishedVersion
author Tamma, Grazia
Valenti, Giovanna
Grossini, Elena
Donnini, Sandra
Marino, Angela
Marinelli, Raúl A.
Calamita, Giuseppe
author_facet Tamma, Grazia
Valenti, Giovanna
Grossini, Elena
Donnini, Sandra
Marino, Angela
Marinelli, Raúl A.
Calamita, Giuseppe
author_sort Tamma, Grazia
title Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
title_short Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
title_full Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
title_fullStr Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
title_full_unstemmed Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
title_sort aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
publisher Hindawi
publishDate 2021
url http://hdl.handle.net/2133/19959
http://hdl.handle.net/2133/19959
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