Hepatocyte and sertoli cell aquaporins, recent advances and research trends

Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regard...

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Detalles Bibliográficos
Autores principales: Bernardino, Raquel L., Marinelli, Raúl A., Maggio, Anna, Gena, Patrizia, Cataldo, Ilaria, Alves, Marco G., Svelto, María, Oliveira, Pedro F., Calamita, Giuseppe
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: MDPI 2021
Materias:
Mitochondria
Reactive Oxygen Species
Metabolic Homeostasis
Non-alcoholic Fatty Liver Disease
Bile Formation
Spermatogenesis
Male Fertility
Acceso en línea:http://hdl.handle.net/2133/19958
http://hdl.handle.net/2133/19958
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19958
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Mitochondria
Reactive Oxygen Species
Metabolic Homeostasis
Non-alcoholic Fatty Liver Disease
Bile Formation
Spermatogenesis
Male Fertility
spellingShingle Mitochondria
Reactive Oxygen Species
Metabolic Homeostasis
Non-alcoholic Fatty Liver Disease
Bile Formation
Spermatogenesis
Male Fertility
Bernardino, Raquel L.
Marinelli, Raúl A.
Maggio, Anna
Gena, Patrizia
Cataldo, Ilaria
Alves, Marco G.
Svelto, María
Oliveira, Pedro F.
Calamita, Giuseppe
Hepatocyte and sertoli cell aquaporins, recent advances and research trends
topic_facet Mitochondria
Reactive Oxygen Species
Metabolic Homeostasis
Non-alcoholic Fatty Liver Disease
Bile Formation
Spermatogenesis
Male Fertility
description Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field.
format article
artículo
publishedVersion
author Bernardino, Raquel L.
Marinelli, Raúl A.
Maggio, Anna
Gena, Patrizia
Cataldo, Ilaria
Alves, Marco G.
Svelto, María
Oliveira, Pedro F.
Calamita, Giuseppe
author_facet Bernardino, Raquel L.
Marinelli, Raúl A.
Maggio, Anna
Gena, Patrizia
Cataldo, Ilaria
Alves, Marco G.
Svelto, María
Oliveira, Pedro F.
Calamita, Giuseppe
author_sort Bernardino, Raquel L.
title Hepatocyte and sertoli cell aquaporins, recent advances and research trends
title_short Hepatocyte and sertoli cell aquaporins, recent advances and research trends
title_full Hepatocyte and sertoli cell aquaporins, recent advances and research trends
title_fullStr Hepatocyte and sertoli cell aquaporins, recent advances and research trends
title_full_unstemmed Hepatocyte and sertoli cell aquaporins, recent advances and research trends
title_sort hepatocyte and sertoli cell aquaporins, recent advances and research trends
publisher MDPI
publishDate 2021
url http://hdl.handle.net/2133/19958
http://hdl.handle.net/2133/19958
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