A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period

For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter...

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Autores principales: Parodi, Roberto Leandro, Lagrutta, Mariana, Tortolo, Mauro, Navall, Estefanía, Rodríguez, María S., Sasia, Gervasio Flavio, de Candia, Lucas F., Gruvman, Matias A., Bottasso, Oscar, Greca, Alcides Alejandro
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: PLOS 2021
Materias:
Febrile Neutropenia
Longitudinal Studies
Anti-Bacterial Agents
Prospective Studies
Hematologic Neoplasms
Feber
Acceso en línea:http://hdl.handle.net/2133/19941
http://hdl.handle.net/2133/19941
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19941
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Febrile Neutropenia
Longitudinal Studies
Anti-Bacterial Agents
Prospective Studies
Hematologic Neoplasms
Feber
spellingShingle Febrile Neutropenia
Longitudinal Studies
Anti-Bacterial Agents
Prospective Studies
Hematologic Neoplasms
Feber
Parodi, Roberto Leandro
Lagrutta, Mariana
Tortolo, Mauro
Navall, Estefanía
Rodríguez, María S.
Sasia, Gervasio Flavio
de Candia, Lucas F.
Gruvman, Matias A.
Bottasso, Oscar
Greca, Alcides Alejandro
A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
topic_facet Febrile Neutropenia
Longitudinal Studies
Anti-Bacterial Agents
Prospective Studies
Hematologic Neoplasms
Feber
description For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk according to MASCC criteria, and 53.6% of patients were already hospitalized at the onset of febrile neutropenia. Bloodstream infections were detected in 14% episodes; whereas an infectious source of fever was identified in 80% of cases. Mortality rate achieved to 14.95%. The binary regression analysis showed that persistence of fever at day 7, or neutropenia at day 14, dehydration and tachycardia at the onset of febrile neutropenia as well as prior infections were significantly associated with mortality. In addition to expanding our current knowledge on the features of adult patients with febrile neutropenia, present findings provide useful information for better management of them in Argentina, given the appropriate representativeness of centers participating in the study.
format article
artículo
publishedVersion
author Parodi, Roberto Leandro
Lagrutta, Mariana
Tortolo, Mauro
Navall, Estefanía
Rodríguez, María S.
Sasia, Gervasio Flavio
de Candia, Lucas F.
Gruvman, Matias A.
Bottasso, Oscar
Greca, Alcides Alejandro
author_facet Parodi, Roberto Leandro
Lagrutta, Mariana
Tortolo, Mauro
Navall, Estefanía
Rodríguez, María S.
Sasia, Gervasio Flavio
de Candia, Lucas F.
Gruvman, Matias A.
Bottasso, Oscar
Greca, Alcides Alejandro
author_sort Parodi, Roberto Leandro
title A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_short A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_full A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_fullStr A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_full_unstemmed A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_sort multicenter prospective study of 515 febrile neutropenia episodes in argentina during a 5-year period
publisher PLOS
publishDate 2021
url http://hdl.handle.net/2133/19941
http://hdl.handle.net/2133/19941
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