Design and characterization of chitosan nanoformulations for the delivery of antifungal agents

Among different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole (TIO) and Econazole (ECO). However, their low water solubility may affect their therapeutic efficiency. Therefore, the aim o...

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Autores principales: Calvo, Natalia Lorena, Sreekumar, Sruthi, Svetaz, Laura, Lamas, María Celina, Moerschbacher, Bruno M., Leonardi, Darío
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: MDPI 2021
Materias:
Chitosan Nanocapsules
Drug Delivery Systems
Antifungal Agents
Biological Activity
Candidiasis, Vulvovaginal
Econazole
Tioconazole
Acceso en línea:http://hdl.handle.net/2133/19686
http://hdl.handle.net/2133/19686
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19686
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Chitosan Nanocapsules
Drug Delivery Systems
Antifungal Agents
Biological Activity
Candidiasis, Vulvovaginal
Econazole
Tioconazole
spellingShingle Chitosan Nanocapsules
Drug Delivery Systems
Antifungal Agents
Biological Activity
Candidiasis, Vulvovaginal
Econazole
Tioconazole
Calvo, Natalia Lorena
Sreekumar, Sruthi
Svetaz, Laura
Lamas, María Celina
Moerschbacher, Bruno M.
Leonardi, Darío
Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
topic_facet Chitosan Nanocapsules
Drug Delivery Systems
Antifungal Agents
Biological Activity
Candidiasis, Vulvovaginal
Econazole
Tioconazole
description Among different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole (TIO) and Econazole (ECO). However, their low water solubility may affect their therapeutic efficiency. Therefore, the aim of this research was to produce a novel chitosan nanocapsule based delivery system comprising of TIO or ECO and to study their suitability in vaginal application. These systems were characterized by their physicochemical properties, encapsulation efficiency, in vitro release, storage stability, cytotoxicity, and in vitro biological activity. Both nanocapsules loaded with TIO (average hydrodynamic size of 146.8 ± 0.8 nm, zeta potential of +24.7 ± 1.1 mV) or ECO (average hydrodynamic size of 127.1 ± 1.5 nm, zeta potential of +33.0 ± 1.0 mV) showed excellent association efficiency (99% for TIO and 87% for ECO). The analysis of size, polydispersity index, and zeta potential of the systems at 4, 25, and 37 ◦C (over a period of two months) showed the stability of the systems. Finally, the developed nanosystems presented fungicidal activity against C. albicans at non-toxic concentrations (studied on model human skin cells). The results obtained from this study are the first step in the development of a pharmaceutical dosage form suitable for the treatment of vaginal candidiasis.
format article
artículo
publishedVersion
author Calvo, Natalia Lorena
Sreekumar, Sruthi
Svetaz, Laura
Lamas, María Celina
Moerschbacher, Bruno M.
Leonardi, Darío
author_facet Calvo, Natalia Lorena
Sreekumar, Sruthi
Svetaz, Laura
Lamas, María Celina
Moerschbacher, Bruno M.
Leonardi, Darío
author_sort Calvo, Natalia Lorena
title Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
title_short Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
title_full Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
title_fullStr Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
title_full_unstemmed Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
title_sort design and characterization of chitosan nanoformulations for the delivery of antifungal agents
publisher MDPI
publishDate 2021
url http://hdl.handle.net/2133/19686
http://hdl.handle.net/2133/19686
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