NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

LC-UV/MS-based metabolomic analysis of the Hawaiian endophytic fungus Paraphaeosphaeria neglecta FT462 led to the identifcation of four unique mercaptolactated γ-pyranol–γ-lactams, paraphaeosphaerides E–H (1–4) together with one γ-lactone (5) and the methyl ester of compound 2 (11). The structure...

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Detalles Bibliográficos
Autores principales:	Li, Chun-shun, Sarotti, Ariel Marcelo, Huang, Peng, Dang, Uyen T., Hurdle, Julian G., Kondratyuk, Tamara P., Pezzuto, John M., Turkson, James, Cao, Shugeng
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	Nature 2021
Materias:	Lycopodiella cernua Paraphaeosphaeria neglecta Biologically Active Secondary Metabolites NF-κB Inhibitors
Acceso en línea:	http://hdl.handle.net/2133/19657 http://hdl.handle.net/2133/19657
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19657
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Lycopodiella cernua Paraphaeosphaeria neglecta Biologically Active Secondary Metabolites NF-κB Inhibitors
spellingShingle	Lycopodiella cernua Paraphaeosphaeria neglecta Biologically Active Secondary Metabolites NF-κB Inhibitors Li, Chun-shun Sarotti, Ariel Marcelo Huang, Peng Dang, Uyen T. Hurdle, Julian G. Kondratyuk, Tamara P. Pezzuto, John M. Turkson, James Cao, Shugeng NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
topic_facet	Lycopodiella cernua Paraphaeosphaeria neglecta Biologically Active Secondary Metabolites NF-κB Inhibitors
description	LC-UV/MS-based metabolomic analysis of the Hawaiian endophytic fungus Paraphaeosphaeria neglecta FT462 led to the identifcation of four unique mercaptolactated γ-pyranol–γ-lactams, paraphaeosphaerides E–H (1–4) together with one γ-lactone (5) and the methyl ester of compound 2 (11). The structures of the new compounds (1–5 and 11) were elucidated through the analysis of HRMS and NMR spectroscopic data. The absolute confguration was determined by chemical reactions with sodium borohydride, hydrogen peroxide, α-methoxy-α-(trifuoromethyl)phenylacetyl chlorides (Mosher reagents), and DP4+NMR calculations. All the compounds were tested against STAT3, A2780 and A2780cisR cancer cell lines, E. coli JW2496, and NF-κB. Compounds 1 and 3 strongly inhibited NF-κB with IC50 values of 7.1 and 1.5μM, respectively.
format	article artículo publishedVersion
author	Li, Chun-shun Sarotti, Ariel Marcelo Huang, Peng Dang, Uyen T. Hurdle, Julian G. Kondratyuk, Tamara P. Pezzuto, John M. Turkson, James Cao, Shugeng
author_facet	Li, Chun-shun Sarotti, Ariel Marcelo Huang, Peng Dang, Uyen T. Hurdle, Julian G. Kondratyuk, Tamara P. Pezzuto, John M. Turkson, James Cao, Shugeng
author_sort	Li, Chun-shun
title	NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
title_short	NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
title_full	NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
title_fullStr	NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
title_full_unstemmed	NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
title_sort	nf-κb inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from hawaiian plant lycopodiella cernua derived fungus paraphaeosphaeria neglecta ft462
publisher	Nature
publishDate	2021
url	http://hdl.handle.net/2133/19657 http://hdl.handle.net/2133/19657
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bdutipo_str	Repositorios
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NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

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