Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways

Around the world, trypanosomatids are known for being etiological agents of several highly disabling and often fatal diseases like Chagas disease (Trypanosoma cruzi), leishmaniasis (Leishmania spp.), and African trypanosomiasis (Trypanosoma brucei). Throughout their life cycle, they must cope with d...

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Autores principales: Tripodi, Karina E. J., Menendez Bravo, Simón M., Cricco, Julia Alejandra
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Hindawi 2020
Materias:
Heme-Proteins
Chagas disease
Trypanosoma cruzi
Trypanosomatids
Heme Biosynthesis
Acceso en línea:http://hdl.handle.net/2133/18323
http://hdl.handle.net/2133/18323
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-18323
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Heme-Proteins
Chagas disease
Trypanosoma cruzi
Trypanosomatids
Heme Biosynthesis
spellingShingle Heme-Proteins
Chagas disease
Trypanosoma cruzi
Trypanosomatids
Heme Biosynthesis
Tripodi, Karina E. J.
Menendez Bravo, Simón M.
Cricco, Julia Alejandra
Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
topic_facet Heme-Proteins
Chagas disease
Trypanosoma cruzi
Trypanosomatids
Heme Biosynthesis
description Around the world, trypanosomatids are known for being etiological agents of several highly disabling and often fatal diseases like Chagas disease (Trypanosoma cruzi), leishmaniasis (Leishmania spp.), and African trypanosomiasis (Trypanosoma brucei). Throughout their life cycle, they must cope with diverse environmental conditions, and the mechanisms involved in these processes are crucial for their survival. In this review, we describe the role of heme in several essential metabolic pathways of these protozoans. Notwithstanding trypanosomatids lack of the complete heme biosynthetic pathway, we focus our discussion in the metabolic role played for important heme-proteins, like cytochromes. Although several genes for different types of cytochromes, involved in mitochondrial respiration, polyunsaturated fatty acid metabolism, and sterol biosynthesis, are annotated at the Tritryp Genome Project, the encoded proteins have not yet been deeply studied. We pointed our attention into relevant aspects of these protein functions that are amenable to be considered for rational design of trypanocidal agents.
format article
artículo
publishedVersion
author Tripodi, Karina E. J.
Menendez Bravo, Simón M.
Cricco, Julia Alejandra
author_facet Tripodi, Karina E. J.
Menendez Bravo, Simón M.
Cricco, Julia Alejandra
author_sort Tripodi, Karina E. J.
title Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
title_short Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
title_full Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
title_fullStr Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
title_full_unstemmed Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
title_sort role of heme and heme-proteins in trypanosomatid essential metabolic pathways
publisher Hindawi
publishDate 2020
url http://hdl.handle.net/2133/18323
http://hdl.handle.net/2133/18323
work_keys_str_mv AT tripodikarinaej roleofhemeandhemeproteinsintrypanosomatidessentialmetabolicpathways
AT menendezbravosimonm roleofhemeandhemeproteinsintrypanosomatidessentialmetabolicpathways
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bdutipo_str Repositorios
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