Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems

For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analyse...

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Autores principales: Pérez, Rocío Laura, Escandar, Graciela Mónica
Lenguaje:Inglés
Publicado: Royal Society of Chemistry 2018
Materias:
Fluorescence
Cyclodextrin
Estrogens
Acceso en línea:http://hdl.handle.net/2133/13469
http://hdl.handle.net/2133/13469
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-13469
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Fluorescence
Cyclodextrin
Estrogens
spellingShingle Fluorescence
Cyclodextrin
Estrogens
Pérez, Rocío Laura
Escandar, Graciela Mónica
Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
topic_facet Fluorescence
Cyclodextrin
Estrogens
description For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry.
author Pérez, Rocío Laura
Escandar, Graciela Mónica
author_facet Pérez, Rocío Laura
Escandar, Graciela Mónica
author_sort Pérez, Rocío Laura
title Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_short Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_full Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_fullStr Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_full_unstemmed Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_sort spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
publisher Royal Society of Chemistry
publishDate 2018
url http://hdl.handle.net/2133/13469
http://hdl.handle.net/2133/13469
work_keys_str_mv AT perezrociolaura spectroflurimetricstudyofestrogencyclodextrininclusioncomplexesinaqueoussystems
AT escandargracielamonica spectroflurimetricstudyofestrogencyclodextrininclusioncomplexesinaqueoussystems
bdutipo_str Repositorios
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