Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment
Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug-seeking and taking, and continued drug use regardless of adverse consequences. Despite years of research, effective treatments for psycho-stimulant addiction have not been identified. Persistent vulnerab...
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| Autores principales: | , , , , , |
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| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2018
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/10561 http://hdl.handle.net/2133/10561 |
| Aporte de: |
| id |
I15-R121-2133-10561 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| topic |
Nucleus Accumbens Cocaine Lithium Chloride Long-term Neuroadaptations Sensitization |
| spellingShingle |
Nucleus Accumbens Cocaine Lithium Chloride Long-term Neuroadaptations Sensitization Cuesta, Santiago Batuecas, Jorgelina Severin, María Julia Funes, Alejandrina Rosso, Silvana Beatriz Pacchioni, Alejandra María Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| topic_facet |
Nucleus Accumbens Cocaine Lithium Chloride Long-term Neuroadaptations Sensitization |
| description |
Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug-seeking and taking, and continued drug use regardless of adverse consequences. Despite years of research, effective treatments for psycho-stimulant addiction have not been identified. Persistent vulnerability to relapse arises from a number of long-lasting adaptations in the reward circuitry that mediate the enduring response to the drug. Recently, we reported that the activity of the canonical or Wnt/β-catenin pathway in the prefrontal cortex (PFC) is very important in the early stages of cocaine-induced neuroadaptations. In the present work, our main goal was to elucidate the relevance of this pathway in cocaine-induced long-term neuroadaptations that may underlie relapse. We found that a cocaine challenge, after a period of abstinence, induced an increase in the activity of the pathway which is revealed as an increase in the total and nuclear levels of β-catenin (final effector of the pathway) in the nucleus accumbens (NAcc), together with a decrease in the activity of glycogen synthase kinase 3β (GSK3β). Moreover, we found that the pharmacological modulation of the activity of the pathway has long-term effects on the cocaine-induced neuroplasticity at behavioral and molecular levels. All the results imply that changes in the Wnt/β-catenin pathway effectors are long-term neuroadaptations necessary for the behavioral response to cocaine. Even though more research is needed, the present results introduce the Wnt canonical pathway as a possible target to manage cocaine long-term neuroadaptations. |
| format |
article artículo publishedVersion |
| author |
Cuesta, Santiago Batuecas, Jorgelina Severin, María Julia Funes, Alejandrina Rosso, Silvana Beatriz Pacchioni, Alejandra María |
| author_facet |
Cuesta, Santiago Batuecas, Jorgelina Severin, María Julia Funes, Alejandrina Rosso, Silvana Beatriz Pacchioni, Alejandra María |
| author_sort |
Cuesta, Santiago |
| title |
Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| title_short |
Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| title_full |
Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| title_fullStr |
Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| title_full_unstemmed |
Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| title_sort |
role of wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment |
| publisher |
Wiley |
| publishDate |
2018 |
| url |
http://hdl.handle.net/2133/10561 http://hdl.handle.net/2133/10561 |
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