Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus

ABSTRACT Objective: To evaluate the clinical usefulness of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion for the detection of early tubular damage in type 2 diabetes mellitus (T2DM). Subjects and methods: Thirty six patients with T2DM were divided into two groups based on urinary albumin...

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Autores principales: Bouvet, Beatriz Reina, Paparella, Cecilia Vicenta, Arriaga, Sandra Mónica María, Monje, Adriana L., Amarilla, Ana María, Almará, Adriana María
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) 2018
Materias:
N-acetyl-beta-D-glucosaminidase
Microalbuminuria
Diabetic Nephropathy
Type 2 Diabetes Mellitus
Tubular Dysfunction
Acceso en línea:http://hdl.handle.net/2133/10488
http://hdl.handle.net/2133/10488
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-10488
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic N-acetyl-beta-D-glucosaminidase
Microalbuminuria
Diabetic Nephropathy
Type 2 Diabetes Mellitus
Tubular Dysfunction
spellingShingle N-acetyl-beta-D-glucosaminidase
Microalbuminuria
Diabetic Nephropathy
Type 2 Diabetes Mellitus
Tubular Dysfunction
Bouvet, Beatriz Reina
Paparella, Cecilia Vicenta
Arriaga, Sandra Mónica María
Monje, Adriana L.
Amarilla, Ana María
Almará, Adriana María
Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
topic_facet N-acetyl-beta-D-glucosaminidase
Microalbuminuria
Diabetic Nephropathy
Type 2 Diabetes Mellitus
Tubular Dysfunction
description ABSTRACT Objective: To evaluate the clinical usefulness of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion for the detection of early tubular damage in type 2 diabetes mellitus (T2DM). Subjects and methods: Thirty six patients with T2DM were divided into two groups based on urinary albumin to creatinine ratio (ACR): normoalbuminuria (ACR <30 mg/g; n=19) and microalbuminuria (ACR= 30-300 mg/g; n=17). The following parameters were determined in both groups: urinary NAG and albumin, serum and urine creatinine, fasting plasma glucose and glycated hemoglobin (HbA1c). Results: Urinary NAG levels [Units/g creatinine; median (range)] were significantly increased in microalbuminuria group [17.0 (5.9 - 23.3)] compared to normoalbuminuria group [4.4 (1.5 - 9.2)] (P<0.001). No differences between groups were observed in fasting glucose, HbA1c and serum creatinine levels. Urinary NAG positively correlated with ACR (r= 0.628; P<0.0001), while no significant association was observed between NAG and glycemia, HbA1c and serum creatinine. Conclusions: The increase of urinary NAG at the microalbuminuria stage of diabetic nephropathy (DN) suggests that tubular dysfunction is already present in this period. The significant positive association between urinary NAG excretion and ACR indicates the possible clinical application of urinary NAG as a complementary marker for early detection of DN in T2DM.
format article
artículo
publishedVersion
author Bouvet, Beatriz Reina
Paparella, Cecilia Vicenta
Arriaga, Sandra Mónica María
Monje, Adriana L.
Amarilla, Ana María
Almará, Adriana María
author_facet Bouvet, Beatriz Reina
Paparella, Cecilia Vicenta
Arriaga, Sandra Mónica María
Monje, Adriana L.
Amarilla, Ana María
Almará, Adriana María
author_sort Bouvet, Beatriz Reina
title Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
title_short Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
title_full Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
title_fullStr Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
title_full_unstemmed Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
title_sort evaluation of urinary n-acetyl-beta-d-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
publisher Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
publishDate 2018
url http://hdl.handle.net/2133/10488
http://hdl.handle.net/2133/10488
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