Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas

More than 40 formulas have been developed to estimate the glomerular filtration rate (GFR) involving creatinine concentration (Cr) as well as demographic and anthropometric variables. Modification of Diet in Renal Disease (MDRD-4) is the most recommended one. However, several studies state that Chro...

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Detalles Bibliográficos
Autores principales: Pezzarini, Eleonora, Rossi, María F., Balbi, Bárbara, Monje, Adriana L., Ocampo Alzate, Carlos, Basiglio, Cecilia Lorena, Rodenas, M., Daniele, Stella Maris, Arriaga, Sandra Mónica María, Pelusa, Héctor Fabián
Otros Autores: Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Formato: conferenceObject documento de conferencia publishedVersion
Lenguaje:Español
Publicado: Instituto de Histología y Embriología “Dr. Mario H. Burgos” (IHEM-CONICET) 2017
Materias:
CKD-EPI
MDRD-4
Glomerular Filtration Rate
Acceso en línea:http://hdl.handle.net/2133/10215
http://hdl.handle.net/2133/10215
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-10215
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Español
orig_language_str_mv spa
topic CKD-EPI
MDRD-4
Glomerular Filtration Rate
spellingShingle CKD-EPI
MDRD-4
Glomerular Filtration Rate
Pezzarini, Eleonora
Rossi, María F.
Balbi, Bárbara
Monje, Adriana L.
Ocampo Alzate, Carlos
Basiglio, Cecilia Lorena
Rodenas, M.
Daniele, Stella Maris
Arriaga, Sandra Mónica María
Pelusa, Héctor Fabián
Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
topic_facet CKD-EPI
MDRD-4
Glomerular Filtration Rate
description More than 40 formulas have been developed to estimate the glomerular filtration rate (GFR) involving creatinine concentration (Cr) as well as demographic and anthropometric variables. Modification of Diet in Renal Disease (MDRD-4) is the most recommended one. However, several studies state that Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation improves the results obtained with MDRD-4. Our aim was to compare the results of the estimated GFR (eGFR) obtained with both formulas in patients with glomerular pathology. We studied 32 individuals with glomerulopathies, age (mean±SD): 34±8 years old, 24 females (F) and 8 males (M). Cr was assessed by an automated method. Results were expressed as mean±SD. eGFR (ml/min) with CKD-EPI and MDRD-4 were 102±41 and 105±51 respectively; no significant differences were obtained between both formulas (p>0.05). Correlation coefficient between both equations was highly significant (r=0.93; p<0.0001). eGFR values were compared by sex and age. Results obtained for CKD-EPI and MDRD-4 by sex were: F: 107±38 and 111±51; M: 85±47 and 86±48, respectively. Results obtained for CKD-EPI and MDRD-4 by age were: < 34 years old: 109±41 and 111±55; ≥ 34 years old: 93±40 and 96±46, respectively. No significant differences were obtained for sex nor age (p>0.05). We conclude that both formulas could be used indistinctly as estimators of GFR in patients with glomerular pathology. For GFR values > normal values, eGFR with both equations would tend to a poorer correlation, then stratification and comparison of these values with those obtained from Cr clearance are suggested in order to determine which equation would be the best analytical predictor in patients with glomerulopathy and glomerular hyperfiltration.
author2 Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
author_facet Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Pezzarini, Eleonora
Rossi, María F.
Balbi, Bárbara
Monje, Adriana L.
Ocampo Alzate, Carlos
Basiglio, Cecilia Lorena
Rodenas, M.
Daniele, Stella Maris
Arriaga, Sandra Mónica María
Pelusa, Héctor Fabián
format conferenceObject
documento de conferencia
publishedVersion
author Pezzarini, Eleonora
Rossi, María F.
Balbi, Bárbara
Monje, Adriana L.
Ocampo Alzate, Carlos
Basiglio, Cecilia Lorena
Rodenas, M.
Daniele, Stella Maris
Arriaga, Sandra Mónica María
Pelusa, Héctor Fabián
author_sort Pezzarini, Eleonora
title Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_short Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_full Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_fullStr Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_full_unstemmed Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_sort estimation of the glomerular filtration rate in patients with glomerular pathology comparing ckd-epi y mdrd-4 formulas
publisher Instituto de Histología y Embriología “Dr. Mario H. Burgos” (IHEM-CONICET)
publishDate 2017
url http://hdl.handle.net/2133/10215
http://hdl.handle.net/2133/10215
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